| Type | Description |
|---|---|
| Definition | Cbl proto-oncogene like 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:41:00 | Downregulation of long non-coding RNA XIST inhibits cell proliferation, migration, invasion and EMT by regulating miR-212-3p/CBLL1 axis in non-small cell lung cancer cells. | 31646569 |
| 2020-06-27 12:29:00 | Study have demonstrated that CBLL1 is highly expressed in non-small lung cancer (NSCLC) cancer tissues compared with corresponding normal lung tissues, and correlated with tumor size. Moreover, CBLL1 promotes the cell proliferation by inducing the G0/G1-S transition and cell invasion by increasing degradation of extracellular matrices of NSCLC cells. | 31124298 |
| 2019-09-14 12:11:00 | we have detected the presence of micrometastasis in the lung mice, further confirming Hakai role during tumour metastasis in vivo. These results lead to the consideration of Hakai as a potential new therapeutic target to block tumour development and metastasis | 29472634 |
| 2018-10-13 10:25:00 | The present study demonstrated for the first time that knockdown of Hakai inhibited the proliferation, migration and invasion of nonsmallcell lung cancer cells, and sensitized nonsmallcell lung cancer cells to cisplatin. | 29786107 |
| 2018-05-19 12:21:00 | findings suggest that the E3 ubiquitin-ligase, such as Hakai, may be a better target than proteasome for using novel specific inhibitors in tumor subtypes that follow EMT. | 28675930 |
| Type | IDs |
|---|---|
| Synonymous | HAKAI, RNF188 |
| Gene |
UniProtKB-ID:
HAKAI_HUMAN,
B4DDV7_HUMAN
UniprotKB:
Q75N03,
B4DDV7
UniParc:
UPI000189A906,
UPI000006E5AC,
UPI00017A6BF0
EMBL:
AC002467,
BC027460,
AK026762,
BC130531,
AK293352,
BC130529,
BC144176
Ensembl:
ENSG00000105879
KO:
hsa:79872
|
| Nucleutide sequences |
EMBL-CDS:
AAS07390.1,
AAH27460.2,
BAB15544.1,
AAI30532.1,
AAI30530.1,
AAI44177.1,
BAG56868.1
Ensembl_TRS:
ENST00000440859,
ENST00000222597
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000222597,
ENSP00000401277
RefSeq:
XP_016868133.1,
XP_024302704.1,
XP_016868132.1,
NP_001271220.1,
XP_024302705.1,
XP_024302706.1,
XP_024302707.1,
XP_016868134.1,
NP_079090.2,
XP_011514882.1
|
| Others |
UniRef100:
UniRef100_Q75N03,
UniRef100_B4DDV7
UniRef90:
UniRef90_Q9JIY2
UniRef50:
UniRef50_Q9JIY2
UniGene:
Hs.592271
CCDS:
CCDS64754.1,
CCDS5747.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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