| Type | Description |
|---|---|
| Definition | charged multivesicular body protein 5 |
| Date | Results | Publications |
|---|---|---|
| 2019-02-23 12:59:00 | Our findings show that CHMP5 is a direct target of MIR429 in human colon cancer cell lines and suggest that CHMP5 up-regulation as a result of reduced MIR429 expression in DSS-induced mice colitis tissues and human UC tissues may restrict apoptosis and promote cell proliferation. | 30334065 |
| 2017-09-02 13:27:00 | CHMP5 is a key sensor of thresholds for signaling via the T cell antigen receptor (TCR) that is essential for T cell development. CHMP5 enabled positive selection by promoting post-selection thymocyte survival in part through stabilization of the pro-survival protein Bcl-2. | 28553951 |
| 2015-10-31 10:23:00 | CHMP5 tunes NF-kappaB signaling downstream of RANK in osteoclasts to dampen osteoclast differentiation, osteoblast coupling and bone turnover rates. | 26195726 |
| 2010-01-21 00:00:00 | CHMP5 regulates late endosome function downstream of MVB formation, and the loss of CHMP5 enhances signal transduction by inhibiting lysosomal degradation of activated receptors. | 16567502 |
| Type | IDs |
|---|---|
| Synonymous | 2210412K09Rik, AW545668 |
| Gene |
UniProtKB-ID:
CHMP5_MOUSE
UniprotKB:
Q9D7S9
UniParc:
UPI0000022EA4
EMBL:
AK147058,
BC006947,
AK008911
Ensembl:
ENSMUSG00000028419
KO:
mmu:76959
|
| Nucleutide sequences |
EMBL-CDS:
AAH06947.1,
BAE27642.1,
BAB25962.1
Ensembl_TRS:
ENSMUST00000030128
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030128
RefSeq:
NP_084090.1
|
| Others |
UniRef100:
UniRef100_Q9D7S9
UniRef90:
UniRef90_Q9NZZ3
UniRef50:
UniRef50_Q9NZZ3
UniGene:
Mm.212763
CCDS:
CCDS18053.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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