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76123 Gpsm2

76123

Gpsm2

G-protein signalling modulator 2 (AGS3-like, C. elegans)

protein-coding

Mus musculus

基因描述

Type Description
Definition G-protein signalling modulator 2 (AGS3-like, C. elegans)

研究结论

Date Results Publications
2020-08-15 19:05:00 Legumain-deficient macrophages promote senescence of tumor cells by sustaining activation. 31857155
2020-04-11 12:03:00 GPSM2-GNAI confers on the first row its unique tallest identity and participates in generating differential row identity across the hair bundle. 30827920
2018-12-22 11:40:00 Mutation of the mouse orthologue of GPSM2 affects actin-rich stereocilia elongation in auditory and vestibular hair cells, causing deafness and balance defects. Gpsm2 defines an approximately 200 nm nanodomain at the tips of stereocilia and this localization requires the presence of Galphai3, myosin 15 and whirlin. Loss of Gpsm2 leads to decreased outgrowth and a disruption of actin dynamics in neuronal growth cones. 28387217
2018-05-19 11:24:00 LGN in complex with the asymmetric domain of Inscuteable, which reveals a tetrameric arrangement of intertwined molecules. 29523789
2017-09-16 11:11:00 LGN and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing. 27660326

名称对应

Type IDs
Synonymous 6230410J09Rik, LGN, Pins
Gene
UniProtKB-ID: GPSM2_MOUSE, Q3UPG3_MOUSE
UniprotKB: Q8VDU0, Q3UPG3
UniParc: UPI000059DE96
EMBL: AK143552, BC021308, AY081187, AK040996
Ensembl: ENSMUSG00000027883
KO: mmu:76123
Nucleutide sequences
EMBL-CDS: AAH21308.1, AAL87447.1, BAC30775.1, BAE25432.1
Ensembl_TRS: ENSMUST00000029482
Protein sequencees
Ensembl_PRO: ENSMUSP00000029482
RefSeq: XP_006502319.1, NP_083798.2
Others
UniRef100: UniRef100_Q8VDU0
UniRef90: UniRef90_Q8VDU0
UniRef50: UniRef50_P81274
UniGene: Mm.226941
CCDS: CCDS51048.1

全选

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研究热度

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