Spaca6 - sperm acrosome associated 6-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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75202 Spaca6

基因描述

Type	Description
Definition	sperm acrosome associated 6

研究结论

Date	Results	Publications
2020-12-19 13:40:00	Sperm protein is required for mammalian Sperm-Egg Adhesion/Fusion.	32210282
2020-08-22 15:26:00	Sperm proteins SOF1, TMEM95, and are required for sperm-oocyte fusion in mice.	32393636
2018-12-22 12:08:00	Our findings suggest a mechanism, by which a decrease in miR-125a-3p during oocyte maturation facilitates GVBD by allowing Fyn up-regulation and the resulting stabilization of the interaction between actin and A-type lamins.	28533542
2015-06-20 12:42:00	Dual-luciferase reporter gene analysis showed that RTEF-1 is a direct target of mir-125a-5p, which regulates angiogenesis by repressing RTEF-1 expression and modulating eNOS and VEGF expression.	25059272
2014-11-29 11:31:00	The Spaca6 gene product may, together with Izumo1, mediate sperm fusion by binding an as yet unidentified egg membrane receptor.	24275887

名称对应

Type	IDs
Synonymous	4930546H06Rik, 9530079D04Rik, B230206P06Rik, Ncrna00085, SPACA6A, let-7e, mir-125a, mir-99b
Gene	UniProtKB-ID: SACA6_MOUSE UniprotKB: E9Q8Q8 UniParc: UPI0001AAB3EB, UPI000058AB2C, UPI0006B2D8CF EMBL: AK016052, AC165361, BC171984, BC171982 Ensembl: ENSMUSG00000080316 KO: mmu:75202
Nucleutide sequences	EMBL-CDS: AAI71984.1, AAI71982.1 Ensembl_TRS: ENSMUST00000172097
Protein sequencees	Ensembl_PRO: ENSMUSP00000128732 RefSeq: XP_036016712.1, XP_006525116.1, NP_001156381.1, XP_011244997.1, XP_036016711.1, XP_011244994.1, XP_017173194.1, XP_006525118.1, XP_006525119.1, XP_030105981.1
Others	UniRef100: UniRef100_E9Q8Q8 UniRef90: UniRef90_E9Q8Q8 UniRef50: UniRef50_E9Q8Q8 UniGene: Mm.227456 CCDS: CCDS49967.1

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
32393636	Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proc Natl Acad Sci U S A Taichi Noda , Yonggang Lu , Yoshitaka Fujihara , Seiya Oura , Takayuki Koyano , Sumire Kobayashi , Martin M Matzuk , Masahito Ikawa	2020-05-26	-
32210282	Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion. Sci Rep Sandrine Barbaux , CÃ´me Ialy-Radio , Myriam Chalbi , Elisa Dybal , MÃ©line Homps-Legrand , Marcio Do Cruzeiro , Daniel Vaiman , Jean-Philippe Wolf , Ahmed Ziyyat	2020-03-24	-
28533542	Regulation of GVBD in mouse oocytes by miR-125a-3p and Fyn kinase through modulation of actin filaments. Sci Rep Hadas Grossman , Efrat Har-Paz , Natalie Gindi , Mattan Levi , Irit Miller , Nava Nevo , Dalia Galiani , Nava Dekel , Ruth Shalgi	2017-05-22	-
25059272	miR-125a-5p impairs endothelial cell angiogenesis in aging mice via RTEF-1 downregulation. Aging Cell Peng Che , Jun Liu , Zhen Shan , Ridong Wu , Chen Yao , Jin Cui , Xiaonan Zhu , Junwei Wang , Mary Susan Burnett , Shenming Wang , JinSong Wang	2014-10-01	Tead4, Spaca6
24275887	A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion. Mamm. Genome Diego Lorenzetti , Christophe Poirier , Ming Zhao , Paul A Overbeek , Wilbur Harrison , Colin E Bishop	2014-04-01	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21677750	A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley	2011-06-15	-
21037258	miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. Ana Kozomara , Sam Griffiths-Jones	2011-01-01	F630028O10Rik, Mirg, Mir22hg, Mir741, Mir743, Mir742, Mir181d, Mir290a, Mir292, Mir294, Mir295, Mir293, Mir291a, Mir18b, Mir193b, Mir208b, Mir344-2, Mir467d, Mir574, Mir598, Mir873a, Mir876, Mir877, Mir881, Mir883a, Mir653, Mir875, Mir92b, Mir291b, Mir504, Mir871, Mir878, Mir880, Mir190b, Mir511, Mir582, Mir874, Mir879, Mir883b, Mir743b, Mir669k, Mir669i, Mir1188, Mir1193, Mir1199, Mir1892, Mir1929, Mir1931, Mir1932, Mir1938, Mir1943, Mir1947, Mir1948, Mir1949, Mir1951, Mir1953, Mir1956, Mir1960, Mir1963, Mir1964, Mir1966, Mir1968, Mir1839, Mir664, Mir1224, Mir1197, Mir1933, Mir1955, Mir1969, Mir1982, Mir1b, Mir669g, Mir1187, Mir1930, Mir1936, Mir1962, Mir1967, Mir1981, Mir669h, Mir1945, Mir1934, Mir3475, Mir3099, Mir3072, Mir3473a, Mir3474, Mir1264, Mir1249, Mir1298, Mir3058, Mir3106, Mir3057, Mir3060, Mir3061, Mir3064, Mir3066, Mir3069, Mir3070a, Mir3071
18799693	Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. Gwenn M Hansen , Diane C Markesich , Michael B Burnett , Qichao Zhu , Karen M Dionne , Lizabeth J Richter , Richard H Finnell , Arthur T Sands , Brian P Zambrowicz , Alejandro Abuin	2008-10-01	Gm11335, Gm17762, A930017K11Rik, BC028777, Gm13999, Gm11696, Gm12359, Gm10589, D030047H15Rik, Gm10856, Gm10685, Gm10062, Gm10433, Gm10648, Gm10840, Gm15441, Gm10684, Gm9900, Gm10822, Gm10687, Gm11744, Gm10747, Arih2os, B230344G16Rik, Fmr1os, Tmem51os1, Gm14488, Gm13033, Gm10789, Gm10615, Gm1976, Gm9967, Gm9917, Gm1974, Gm11496, Gm13580, Gm2085, Gm2183, Gm2245, Tbx3os1, Gm12980, Gm2329, Lncenc1, Gm2381, Snhg12, Gm2479, Gm12942, Gm2529, Gm2533, Rpl30-ps7, Rsf1os2, Gm2695, 2810416G20Rik, Rpl30-ps6, Gm2773, Gm2788, Dynlt1f, Gm9793, Gm2885, Gm2920, Gm15506, Gm11627, Gm10518, Gm13496, Gm3134, Gm12827, Gm3143, Gm10144, Ahnak2, Gm3196, Gm13242, Gm3325, Gm13247, Gm10863, Gm13157, 4930522L14Rik, Gm3552, Gm15226, Gm3604, Gm3643, BC005561, Gm3716, 2810410L24Rik, Gm10282, Gm3839, Nhsl2, 4732419C18Rik, Gm3906, Gm3973, Gm4013, Apol7d, Gm12057, Gm10489, Rex2, 1110002L01Rik, Gm4189, Gm4204, 4632428C04Rik, 9130023H24Rik
17967808	EUCOMM--the European conditional mouse mutagenesis program. Brief Funct Genomic Proteomic Roland H Friedel , Claudia Seisenberger , Cornelia Kaloff , Wolfgang Wurst	2007-09-01	Gm11696, Gm10589, Apela, Gm10822, Gm2085, Gm2312, Lncenc1, Gm2381, Gm2659, Gm2679, Dynlt1c, Gm3134, Gm3143, Gm3236, Gm3574, Gm3581, Gm3718, Gm3859, Gm3905, Gm3952, Gm3957, Gm3973, Gm12057, Rex2, Gm4218, Gm4225, Gm16476, Gm4407, Gm14410, Gm4420, Gm14005, 1300002E11Rik, Gm4532, Srcap, Gm17789, Gm10751, Gm14321, 0610009E02Rik, Gm12758, Gm11532, Phactr4, Rusc2, AK010878, Gm10778, 5830417I10Rik, Mir1902, Gm15270, Gm11767, Ino80dos, Bsdc1, Gm7645, Gm20590, Slc44a1, Gm15545, Gm17292, 2900009J06Rik, Kifc1, Gm13150, Gm19426, Gm19428, Gm19474, Gm14963, Gm19565, Gm19592, Gm12588, Snhg4, Gm19702, Gm19705, Platr22, Nuggc, Zfp534, Gm19860, Gm11725, Gm19876, Gm19889, Gm16201, Gm13056, Tnfsf13os, Gm19925, Gm19976, Gm20014, Gm16740, Gm20039, Gm20045, AU020206, Ccdc170, Trp53cor1, Gm20266, Gm20324, Zfp518b, Gm14401, AI480526, Pds5b, Ube3c, Gm21297, Akap9, Gm29724, Itfg2, Parp11

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