| Type | Description |
|---|---|
| Definition | NKD inhibitor of WNT signaling pathway 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-03-31 10:22:00 | This work reveals that the zebrafish Nkd1 EF-hand is essential to balance Wnt signaling inputs and modulate the appropriate outputs, while the Drosophila-like EF-Hand primarily functions in beta-catenin signaling. | 29180104 |
| 2016-05-21 10:59:00 | Nkd1 activity is specifically dependent on Wnt ligand activation of the receptor. Nkd1 is recruited to the Wnt signalosome with Dvl2, where it becomes activated to move into the cytoplasm to interact with beta-catenin, inhibiting its nuclear accumulation. | 25904337 |
| 2014-04-19 11:52:00 | Nkd1 functions as a passive antagonist of Wnt signaling, functioning only when homeostatic levels of Wnt signaling have been breached or when Wnt signaling becomes destabilized. | 24009776 |
| 2011-08-27 11:30:00 | Data demonstrate that Nkd1 binds to beta-catenin and prevents its nuclear accumulation. Nkd1 function is dependent on its interaction with the cell membrane. | 21490931 |
| 2011-01-01 11:34:00 | Nkd1 knockdown in the dorsal forerunner cells causes beta-catenin nuclear localization/transcriptional activation & changes in DFC migration, Kupffer's vesicle formation, ciliogenesis, left-right patterning, & asymmetric charon expression. | 20858476 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
NKD1_DANRE,
A0A1I7Q3W8_DANRE,
B0S7E2_DANRE
UniprotKB:
Q2TJA6,
A0A1I7Q3W8,
B0S7E2
UniParc:
UPI0000679FE8,
UPI0003836501
EMBL:
BC163392,
BC163386,
AY863053,
CU929130,
BX664719
Ensembl:
ENSDARG00000020053
KO:
dre:751108
|
| Nucleutide sequences |
EMBL-CDS:
AAX55756.1,
AAI63392.1,
AAI63386.1
Ensembl_TRS:
ENSDART00000173523,
ENSDART00000052379
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000142757,
ENSDARP00000052378
RefSeq:
XP_005169061.1,
NP_001036798.1
|
| Others |
UniRef100:
UniRef100_Q2TJA6,
UniRef100_A0A1I7Q3W8
UniRef90:
UniRef90_Q2TJA6
UniRef50:
UniRef50_Q2TJA6
UniGene:
Dr.135817
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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