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7444 VRK2

7444

VRK2

VRK serine/threonine kinase 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition VRK serine/threonine kinase 2

研究结论

Date Results Publications
2019-09-28 11:04:00 our work reveals the regulation of dysbindin by VRK2, providing the association of these two proteins, which are commonly implicated in schizophrenia 30062698
2019-02-23 11:58:00 Structural characterization of human vaccinia-related kinases, VRK1 and VRK2, bound to small-molecule inhibitors, has been reported. 28790404
2019-02-23 11:47:00 a novel insight into the oncogenic activity of VRK2-Akt complexes in the lysosomes via modulation of autophagy 29872222
2018-09-01 11:15:00 VRK2 is suggested as a candidate gene for neurological disorders through its role in signaling pathway, the neuronal loss and stress response. 29100046
2018-05-26 11:22:00 GSK3beta may inhibit VRK2 catalytic activity by disrupting its flexibility. The inhibition of VRK2 catalytic activity by GSK3beta may also inhibit VRK2-induced degradation of TRiC, which could suppress polyQ-expanded Htt aggregation. 27377031

名称对应

Type IDs
Gene
UniProtKB-ID: VRK2_HUMAN, A8K9L2_HUMAN
UniprotKB: Q86Y07, A8K9L2
UniParc: UPI00001D8A7C, UPI00000622D0, UPI00000622CE, UPI000013D498, UPI0000D4EA29, UPI00006A781D
EMBL: AK223540, CH471053, BC027854, AC073215, AC068193, AY228370, AC007250, AY228367, AY228372, AY228371, AJ512204, AY228368, AK292727, AK296611, AY228369, AB000450
Ensembl: ENSG00000028116
KO: hsa:7444
Nucleutide sequences
EMBL-CDS: AAO73052.1, AAH27854.1, AAX93262.1, BAD97260.1, AAY14648.1, BAG59222.1, AAO73050.1, EAX00066.1, AAO73048.1, EAX00068.1, AAO73049.1, CAD54446.2, AAO73047.1, EAX00067.1, EAX00064.1, EAX00062.1, BAA19109.1, AAO73051.1, AAY15019.1, BAF85416.1
Ensembl_TRS: ENST00000435505, ENST00000412104, ENST00000340157, ENST00000648897, ENST00000417641, ENST00000440705
Protein sequencees
Ensembl_PRO: ENSP00000402375, ENSP00000408002, ENSP00000342381, ENSP00000497378, ENSP00000404156, ENSP00000398323
RefSeq: NP_001123954.1, NP_006287.2, NP_001123955.1, XP_006712156.1, NP_001123952.1, NP_001275767.1, NP_001275766.1, XP_016860348.1, XP_016860355.1, NP_001123953.1, XP_006712154.1, XP_011531394.1, NP_001275765.1, XP_016860351.1, XP_016860354.1, NP_001275768.1, XP_016860350.1, XP_016860349.1, XP_016860347.1, XP_006712155.1, XP_006712153.1, XP_005264597.1, XP_016860352.1
Others
UniRef100: UniRef100_Q86Y07, UniRef100_A8K9L2
UniRef90: UniRef90_Q86Y07, UniRef90_Q86Y07-2
UniRef50: UniRef50_Q86Y07-2, UniRef50_Q86Y07
UniGene: Hs.744058
CCDS: CCDS1859.1, CCDS46291.1, CCDS46292.1

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