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7365 UGT2B10

7365

UGT2B10

UDP glucuronosyltransferase family 2 member B10

protein-coding

Homo sapiens

基因描述

Type Description
Definition UDP glucuronosyltransferase family 2 member B10

研究结论

Date Results Publications
2019-09-21 11:47:00 a cis-regulatory SNP for human UGT2B10 29431853
2019-02-16 10:51:00 The high prevalence of a UGT2B10 splice variant among African Americans results in lower 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), - N-glucuronidation but only a small decrease in total NNAL glucuronidation. Therefore, despite the significant contribution of UGT2B10 to NNAL- N-glucuronidation, the UGT2B10 genotype does not play a large role in NNAL detoxication. 29460622
2018-11-17 10:05:00 UGT2B10 was for the first time identified as an N-glucosidation enzyme. Generated N-glucosides were excreted primarily by the BCRP transporter. 29691239
2018-11-10 12:22:00 A significant contribution of AS in the regulation of UGT2B10 expression in the liver. 29438977
2018-04-14 10:05:00 UGT2B10 activity or genotype should be considered when using cotinine as a tobacco exposure biomarker, particularly in populations such as African American with high frequencies of UGT2B10 nonfunctional variants. 28264876

名称对应

Type IDs
Synonymous UDPGT2B10
Gene
UniProtKB-ID: UDB10_HUMAN
UniprotKB: P36537
UniParc: UPI0000137A96, UPI00004804DA
EMBL: CH471057, BC113649, AK298432, AK292738, X63359, AC021146
Ensembl: ENSG00000109181, ENSG00000275190
KO: hsa:7365
Nucleutide sequences
EMBL-CDS: CAA44961.1, BAF85427.1, EAX05577.1, BAG60653.1, AAI13650.1
Ensembl_TRS: ENST00000265403, ENST00000615213, ENST00000627047, ENST00000458688
Protein sequencees
Ensembl_PRO: ENSP00000265403, ENSP00000478760, ENSP00000486876, ENSP00000413420
RefSeq: NP_001138239.1, XP_016864074.1, NP_001066.1, NP_001277020.1
Others
UniRef100: UniRef100_P36537
UniRef90: UniRef90_P36537
UniRef50: UniRef50_P16662
UniGene: Hs.201634
CCDS: CCDS75136.1, CCDS75135.1

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