Protecting PTEN in the Nucleus.
Cancer Discov. 2017 Apr;7(4):OF1. Epub 2017 Mar 03
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摘要
A recent study shows that the transport receptor Importin-11 relocates PTEN, a tumor suppressor, to the nucleus, preventing its degradation in the cytoplasm. Mice lacking Importin-11 are prone to lung cancers, and its absence in human prostate and lung tumors signals a poorer prognosis.
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基因功能
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原始数据
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文献解读
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