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729359 PLIN4

729359

PLIN4

perilipin 4

protein-coding

Homo sapiens

基因描述

Type Description
Definition perilipin 4

研究结论

Date Results Publications
2020-06-27 10:10:00 These findings underlie the importance of a novel morphologic-metabolic phenotype associated with chemotherapy resistance in triple-negative breast cancer , and bring to light novel therapeutic targets resulting from vulnerabilities in this phenotype, including the expression of PLIN4 essential for stabilizing lipid droplets in resistant cells. 31537618
2019-08-17 10:42:00 We investigated whether the presence of the A allele of rs8887 SNP (PLIN4 gene), known to be associated with increased sensitivity to the consumption of n-3 PUFAs, interacts with fetal growth influencing inhibitory control. There was a significant interaction between birth weight and the presence of the A allele on SSRT performance,in which lower birth weight associated with poorer inhibitory control only in non-carrier 30293593
2018-12-22 11:21:00 Using synthetic lipids, we show that Plin4 amphipathic helix (AH) binds poorly to lipid bilayers but strongly interacts with pure triglycerides, acting as a coat and forming small oil droplets. Because Plin4 overexpression alleviates lipid droplet (LD) instability under conditions where their coverage by phospholipids is limiting, we propose that the Plin4 AH replaces the LD lipid monolayer, for example during LD growth. 29626194
2018-03-10 12:03:00 Studied weight loss in obese patients with Perilipin 4 (PLIN4), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4, FTO, ADRB3 polymorphisms. 29361938
2012-09-29 10:45:00 PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle. 22667335

名称对应

Type IDs
Synonymous KIAA1881, S3-12
Gene
UniProtKB-ID: A0A0J9YXN7_HUMAN
UniprotKB: A0A0J9YXN7
UniParc: UPI000387DB1F
EMBL: AC011498
Ensembl: ENSG00000167676
Nucleutide sequences
Ensembl_TRS: ENST00000633942
Protein sequencees
Ensembl_PRO: ENSP00000488481
RefSeq: XP_016882683.1, NP_001354797.1, XP_016882682.1, XP_011526535.1, XP_006722929.1, XP_016882681.1
Others
UniRef100: UniRef100_A0A0J9YXN7
UniRef90: UniRef90_Q96Q06
UniRef50: UniRef50_Q96Q06
UniGene: Hs.591387

全选

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研究热度

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