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Moderating effect of PLIN4 genetic variant on impulsivity traits in 5-year-old-children born small for gestational age.

Prostaglandins Leukot. Essent. Fatty Acids. 2018 Oct;137:19-25. Epub 2018 Jul 27
Danitsa Marcos Rodrigues 1 , Gisele Gus Manfro 1 , Robert Daniel Levitan 2 , Meir Steiner 3 , Michael Joseph Meaney 4 , Patrícia Pelufo Silveira 5
Danitsa Marcos Rodrigues 1 , Gisele Gus Manfro 1 , Robert Daniel Levitan 2 , Meir Steiner 3 , Michael Joseph Meaney 4 , Patrícia Pelufo Silveira 5
+ et al

[No authors listed]

Author information
  • 1 Postgraduate Program in Neurosciences, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • 2 Department of Psychiatry, University of Toronto and Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • 3 Department of Psychiatry and Behavioural Neurosciences, McMaster University. Hamilton, ON, Canada.
  • 4 Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada; Sackler Program for Epigenetics & Psychobiology, McGill University, Canada.
  • 5 Postgraduate Program in Neurosciences, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada; Sackler Program for Epigenetics & Psychobiology, McGill University, Canada. Electronic address: patricia.silveira@mcgill.ca.

摘要

Poor fetal growth is associated with long-term behavioral, metabolic and psychiatric alterations, including impulsivity, insulin resistance, and mood disorders. However, the consumption of omega-3 polyunsaturated fatty acid (n-3 PUFA) seems to be protective for this population, improving inhibitory control and behavioral reactivity. We investigated whether the presence of the A allele of rs8887 SNP (PLIN4 gene), known to be associated with increased sensitivity to the consumption of n-3 PUFAs, interacts with fetal growth influencing inhibitory control. 152 five-year-old children were genotyped and performed the Stop Signal Task (SSRT). There was a significant interaction between birth weight and the presence of the A allele on SSRT performance, in which lower birth weight associated with poorer inhibitory control only in non-carriers. These results suggest that a higher responsiveness to n-3 PUFAS protects small for gestational age children from developing poor response inhibition, highlighting that optimizing n-3 PUFA intake may benefit this population.

KEYWORDS: Impulsivity, Inhibitory control, Lipid droplet storage,, Omega-3 polyunsaturated fatty acids, Single nucleotide polymorphism, Small for gestational age

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