| Type | Description |
|---|---|
| Definition | SET domain containing 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 10:48:00 | Setd5 haploinsufficiency impairs the proliferative dynamics of neural progenitors and synaptic wiring of neurons, ultimately resulting in behavioral deficits in mice. Setd5 gene loss leads to abnormal transcription, with impaired RNA maturation causing detrimental effects on gene integrity and splicing. | 31515109 |
| 2019-05-25 10:52:00 | A specific subpopulation of fetal Setd5(+/-) cortical neurons showed altered gene expression of neurodevelopment-related genes. Setd5(+/-) animals manifested several autism-like behaviors, including hyperactivity, cognitive deficit, and altered social interactions. Anatomical differences were observed in Setd5(+/-) adult brains, accompanied by a deficit of deep-layer cortical neurons in the developing brain. | 30655503 |
| 2019-05-18 12:09:00 | Setd5-haploinsufficient mice present abnormal brain-to-body weight ratios and neural crest defect-associated phenotypes. Setd5-mutant mice show impairments in cognitive tasks, enhanced LTP, delayed ontogenetic profile of ultrasonic vocalization, and behavioral inflexibility. Behavioral issues are accompanied by abnormal expression of postsynaptic density proteins previously associated with cognition. | 30455454 |
| 2018-03-31 10:22:00 | Both SetD5 and BRD2 bind to the transcription start site and to upstream promoter regions of the Sema3a locus and BRD2 is necessary for the regulation of Sema3A expression by SetD5. | 29180574 |
| 2017-09-16 11:12:00 | The findings suggest that SETD5 is essential for regulating histone acetylation during gene transcription and plays a vital role in mammalian embryonic development, and cell cycle progression. | 27864380 |
| Type | IDs |
|---|---|
| Synonymous | 2900045N06Rik, C330007C20, C85544, mKIAA1757 |
| Gene |
UniProtKB-ID:
SETD5_MOUSE
UniprotKB:
Q5XJV7
UniParc:
UPI00000EB5B7,
UPI00001A962B,
UPI0000DBED75
EMBL:
BC083184,
AK053541,
AK122551,
AK049143
Ensembl:
ENSMUSG00000034269
KO:
mmu:72895
|
| Nucleutide sequences |
EMBL-CDS:
BAC35420.1,
BAC65833.1,
BAC33569.1,
AAH83184.1
Ensembl_TRS:
ENSMUST00000113157,
ENSMUST00000042889,
ENSMUST00000113155
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000108782,
ENSMUSP00000047398,
ENSMUSP00000108780
RefSeq:
XP_036008229.1,
XP_036008233.1,
XP_030111469.1,
XP_036008235.1,
XP_011239784.1,
XP_030111480.1,
XP_036008234.1,
XP_036008224.1,
XP_011239787.1,
XP_011239786.1,
XP_036008227.1,
XP_036008236.1,
XP_030111472.1,
XP_036008225.1,
XP_030111484.1,
NP_766593.1,
XP_030111482.1,
XP_036008223.1,
XP_030111471.1,
XP_017177261.1,
XP_036008228.1,
XP_036008232.1,
XP_006506740.1,
XP_036008237.1,
XP_030111483.1,
XP_036008226.1,
XP_017177260.1,
XP_036008238.1,
XP_030111476.1,
XP_036008230.1,
XP_011239782.1,
XP_030111481.1,
XP_030111468.1,
XP_030111477.1,
XP_030111478.1,
NP_082661.1,
XP_030111473.1,
XP_036008231.1,
XP_030111474.1,
XP_030111470.1,
XP_030111467.1
|
| Others |
UniRef100:
UniRef100_Q5XJV7
UniRef90:
UniRef90_Q5XJV7
UniRef50:
UniRef50_Q9C0A6
UniGene:
Mm.367159
CCDS:
CCDS90096.1,
CCDS20411.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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