例如:"lncRNA", "apoptosis", "WRKY"

miR-126-5p promotes retinal endothelial cell survival through SetD5 regulation in neurons.

Development. 2018 Jan 08;145(1)
Gaëlle Villain 1 , Loïc Poissonnier 1 , Baraa Noueihed 2 , Gaëlle Bonfils 1 , Jose Carlos Rivera 2 , Sylvain Chemtob 2 , Fabrice Soncin 1 , Virginie Mattot 3
Gaëlle Villain 1 , Loïc Poissonnier 1 , Baraa Noueihed 2 , Gaëlle Bonfils 1 , Jose Carlos Rivera 2 , Sylvain Chemtob 2 , Fabrice Soncin 1 , Virginie Mattot 3
+ et al

[No authors listed]

Author information
  • 1 University of Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Target Therapies, F-59000 Lille, France.
  • 2 Department of Pediatrics, Ophthalmology, and Pharmacology, CHU Sainte-Justine Research Center, Université de Montréal, Montréal, H1T 2M4 Québec, Canada.
  • 3 University of Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Target Therapies, F-59000 Lille, France virginie.mattot@ibl.cnrs.fr.

摘要


locus and BRD2 is necessary for the regulation of Sema3A expression by SetD5. Thus, neuronally expressed miR-126-5p regulates angiogenesis by protecting endothelial cells of the developing retinal vasculature from apoptosis.

KEYWORDS: BRD2, Mouse, Retinal vascular development, Sema3A, SetD5, miR-126-5p