TLE2 - TLE family member 2, transcriptional corepressor-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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7089 TLE2

基因描述

Type	Description
Definition	TLE family member 2, transcriptional corepressor

研究结论

Date	Results	Publications
2010-02-22 11:39:00	Immunofluorescence analysis showed that TLE2 and RTA were colocalized in the same nuclear compartment in KSHV-infected cells.	19939918

名称对应

Type	IDs
Synonymous	ESG, ESG2, GRG2
Gene	UniProtKB-ID: TLE2_HUMAN, K7EMK7_HUMAN UniprotKB: Q04725, K7EMK7 UniParc: UPI0000137038, UPI0000203012, UPI0001891ACB, UPI00019294FD EMBL: BC017364, AC011549, AC007766, AC093053, AK308137, AK293407, M99436 Ensembl: ENSG00000065717 KO: hsa:7089
Nucleutide sequences	EMBL-CDS: BAG56914.1, AAD38075.1, AAA61193.1, AAH17364.1 Ensembl_TRS: ENST00000455444, ENST00000262953, ENST00000426948, ENST00000591529, ENST00000443826, ENST00000590536
Protein sequencees	Ensembl_PRO: ENSP00000468279, ENSP00000413107, ENSP00000262953, ENSP00000392869, ENSP00000392427, ENSP00000466542 RefSeq: NP_001287775.1, XP_011526532.1, NP_001138234.1, NP_003251.2, NP_001138233.1, XP_006722927.1
Others	UniRef100: UniRef100_K7EMK7, UniRef100_Q04725 UniRef90: UniRef90_Q04725, UniRef90_K7EMK7 UniRef50: UniRef50_Q04725 UniGene: Hs.332173 CCDS: CCDS45911.1, CCDS45913.1, CCDS45912.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
30945288	Inflammation-dependent overexpression of c-Myc enhances CRL4^DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. J. Pathol. Hong Liu , Wenzhu Lu , Hongbo He , Jin Wu , Caiguo Zhang , Hanlin Gong , Chunmei Yang	2019-08-01	-
30652415	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. Cancer Med Yan Liu , Jian Li , Zhifang Ma , Jun Zhang , Yuzhi Wang , Zhenghong Yu , Xue Lin , Zhi Xu , Qian Su , Li An , Yehui Zhou , Xinxing Ma , Yiwen Yang , Feifei Wang , Qingfei Chen , Yunchao Zhang , Jilinlin Wang , Huilin Zheng , Aihua Shi , Shuang Yu , Jingzhong Zhang , Weiyong Zhao , Liming Chen	2019-02-01	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
22664934	Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. Daniel BÃ¶hm , Ksenia Keller , Julia Pieter , Nils Boehm , Dominik Wolters , Wulf Siggelkow , Antje Lebrecht , Marcus Schmidt , Heinz KÃ¶lbl , Norbert Pfeiffer , Franz-Hermann Grus	2012-08-01	LOC101060157, USPL1, SCGB1D1, STAG3, MTHFD2, POP1, PRR4, ELFN2, MRGPRD, CLIC1, LRRK2, LRIG3, ZG16B, COL7A1, RBBP8NL, TTBK2, CST1, CST2, TMC8, CST4, DDB1, FREM3, DLG3, DMBT1, KRT78, ZFC3H1, SERPINB1, ENO1, ENO2, ENO3, ABCA3, ALB, ALDH3A1, CEP164, CNOT1, SIPA1L3, PMPCA, SULF1, KIAA0556, MCF2L, DMXL2, ZCCHC11, ALOX5, KLHL34, GNL3, KAT2A, MDGA1, GLE1, PRTG, LCN1P1, MRPL18, GSTP1, ANXA1, ANXA2, ANXA13, HP, HSPB1, APOA1, KLHL17, ACTBL2, IGHA1, IGHA2, IGHG2, IGHG3, IGHG4, JCHAIN, IGKC, IGLC1, IGLC2, MROH7, KRT1, KRT9, TRIM75P, LCN1, LCN2, LCP1, LGALS3, LOC400576, LTF, LYZ, MDH1, MECP2, SCGB2A1, MOV10, LOC439951, POTEE, ATP4A, PRDX1, PRKAG2, PDE4C, PIGR, PIP, PRKAG3, SEMA4C, LIME1, WDR60, NDUFAF7, ZNF446, SLF2
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
20211142	An atlas of combinatorial transcriptional regulation in mouse and man. Cell Timothy Ravasi , Harukazu Suzuki , Carlo Vittorio Cannistraci , Shintaro Katayama , Vladimir B Bajic , Kai Tan , Altuna Akalin , Sebastian Schmeier , Mutsumi Kanamori-Katayama , Nicolas Bertin , Piero Carninci , Carsten O Daub , Alistair R R Forrest , Julian Gough , Sean Grimmond , Jung-Hoon Han , Takehiro Hashimoto , Winston Hide , Oliver Hofmann , Atanas Kamburov , Mandeep Kaur , Hideya Kawaji , Atsutaka Kubosaki , Timo Lassmann , Erik van Nimwegen , Cameron Ross MacPherson , Chihiro Ogawa , Aleksandar Radovanovic , Ariel Schwartz , Rohan D Teasdale , Jesper TegnÃ©r , Boris Lenhard , Sarah A Teichmann , Takahiro Arakawa , Noriko Ninomiya , Kayoko Murakami , Michihira Tagami , Shiro Fukuda , Kengo Imamura , Chikatoshi Kai , Ryoko Ishihara , Yayoi Kitazume , Jun Kawai , David A Hume , Trey Ideker , Yoshihide Hayashizaki	2010-03-05	-
19939918	Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol Zhiheng He , Yunhua Liu , Deguang Liang , Zhuo Wang , Erle S Robertson , Ke Lan	2010-02-01	-
19460168	Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. BMC Cancer Laura Arce , Kira T Pate , Marian L Waterman	2009-05-21	-
17041588	CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat. Cell Biol. Leigh Ann Higa , Min Wu , Tao Ye , Ryuji Kobayashi , Hong Sun , Hui Zhang	2006-11-01	Ddb1, Wdr59, Wdr61, Wdr5b, Wdr82, escl, Cul4, Rbbp5, CG7611, CSN5, l(2)dtl, l(2)09851, dup, wds, WDR5, DDB1, DDB2, POC1B, WDR53, PAFAH1B1, DTL, NLE1, WDR5B, SMU1, WDR12, RBBP5, RFWD2, TLE1, TLE2, TLE3, WDR59, WDR76, WDR26, WDR82, WDR61, HIST1H3A, GRWD1, CUL4B, CUL4A, EED, CIAO1, SNRNP40
15768032	Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat. Struct. Mol. Biol. Danette L Daniels , William I Weis	2005-04-01	Ctnnb1, Lef1, Tle1, Tle2, CTNNB1, LEF1, TLE1, TLE2

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