| Type | Description |
|---|---|
| Definition | secreted phosphoprotein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 11:17:00 | SPP2 expression was decreased in colorectal cancer, leukemia, liver cancer and pancreatic cancer. | 31849319 |
| 2017-03-10 17:58:00 | Spp24 can inhibit the growth of prostate cancer and its bone metastasis induced by BMP2; spp24 may have great potential to be a therapeutic agent in clinical situations | 27793899 |
| 2016-08-20 11:03:00 | the two mutations of SPP2 have dominant negative effects and cellular accumulation of Spp-24 might be particularly toxic to photoreceptors and/or retinal pigment epithelium. SPP2 has a new role in retinal degeneration. | 26459573 |
| 2016-03-26 11:30:00 | Report describes a C-terminal fragment within SPP24 that is distinct from the cystatin domain and which independently binds to BMP-2 and TGF-beta. This fragment inhibited BMP-2 activity in an ectopic bone forming assay. | 25418420 |
| 2016-02-20 11:55:00 | Spp24, or proteolytic products of Spp24, bind cytokines of the TGF-beta superfamily and also activate intracellular signaling pathways [review] | 25339413 |
| Type | IDs |
|---|---|
| Synonymous | SPP-24, SPP24 |
| Gene |
UniProtKB-ID:
SPP24_HUMAN
UniprotKB:
Q13103
UniParc:
UPI0000135D66
EMBL:
CH471063,
U20530,
AC006037,
BC069401,
BC112438,
BC106705,
AJ272265,
AJ308099
Ensembl:
ENSG00000072080
KO:
hsa:6694
|
| Nucleutide sequences |
EMBL-CDS:
AAH69401.1,
AAI06706.1,
CAC87050.1,
CAB75571.1,
AAA87905.1,
AAI12439.1,
EAW71070.1,
AAX93090.1
Ensembl_TRS:
ENST00000168148,
ENST00000373368
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000362466,
ENSP00000168148
RefSeq:
XP_011510000.1,
NP_008875.1,
XP_011510002.1,
XP_005246159.1,
XP_011510001.1
|
| Others |
UniRef100:
UniRef100_Q13103
UniRef90:
UniRef90_Q13103
UniRef50:
UniRef50_Q13103
UniGene:
Hs.444488
CCDS:
CCDS2511.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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