| Type | Description |
|---|---|
| Definition | sodium voltage-gated channel beta subunit 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-08-24 10:50:00 | this study reports the cryo-electron microscopy structures of the human Nav1.7-beta1-beta2 complex bound to two combinations of pore blockers and gating modifier toxins (GMTs), tetrodotoxin with protoxin-II and saxitoxin with huwentoxin-IV, both determined at overall resolutions of 3.2 angstroms. | 30765606 |
| 2018-05-05 11:13:00 | Findings add to the understanding of beta2 role in Nav 1.5 trafficking and localisation, which must influence cell excitability and electrical coupling in the heart. | 28597987 |
| 2016-10-29 11:04:00 | The authors identified a flexible loop formed by (72)Cys and (75)Cys, a unique feature among the four beta-subunit isoforms. | 26894959 |
| 2016-07-16 10:08:00 | Contribution of Cardiac Sodium Channel beta-Subunit Variants to Brugada Syndrome. | 26179811 |
| 2016-03-12 11:02:00 | In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes. | 25757662 |
| Type | IDs |
|---|---|
| Synonymous | ATFB14 |
| Gene |
UniProtKB-ID:
SCN2B_HUMAN,
Q5U0K8_HUMAN
UniprotKB:
O60939,
Q5U0K8
UniParc:
UPI000000165E
EMBL:
U87555,
AF007783,
AF049498,
AK313891,
BT019487,
AY358945,
AF049497,
AF107028,
BC036793,
AF049496,
CH471065
Ensembl:
ENSG00000149575
KO:
hsa:6327
|
| Nucleutide sequences |
EMBL-CDS:
AAC26013.1,
AAH36793.1,
AAF21472.1,
AAQ89304.1,
AAC05208.1,
AAC05274.1,
AAD47196.1,
EAW67353.1,
BAG36614.1,
AAV38294.1
Gene_ORFName:
UNQ326/PRO386,
hCG_41149
Ensembl_TRS:
ENST00000278947
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000278947
RefSeq:
NP_004579.1
|
| Others |
UniRef100:
UniRef100_O60939
UniRef90:
UniRef90_O60939
UniRef50:
UniRef50_O60939
UniGene:
Hs.129783
CCDS:
CCDS8390.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员