OPRPN - opiorphin prepropeptide-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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58503 OPRPN

基因描述

Type	Description
Definition	opiorphin prepropeptide

研究结论

Date	Results	Publications
2010-01-21 00:00:00	Results report the discovery of opiorphin, a previously uncharacterized physiological inhibitor of enkephalin-inactivating zinc ectopeptidases in humans.	17101991
2010-01-21 00:00:00	All members of the human opiorphin family of genes can potentially modulate erectile physiology. Both hSMR3 and ProL1 are down-regulated in the corpora of men with ED, and therefore both genes can potentially act as markers of ED.	18410445

名称对应

Type	IDs
Synonymous	BPLP, PRL1, PROL1, opiorphin
Gene	UniProtKB-ID: PROL1_HUMAN UniprotKB: Q99935 UniParc: UPI000020BE52 EMBL: AC106884, CH471057, S83198 Ensembl: ENSG00000171199 KO: hsa:58503
Nucleutide sequences	EMBL-CDS: EAX05620.1, AAB46823.1 Ensembl_TRS: ENST00000399575
Protein sequencees	Ensembl_PRO: ENSP00000382485 RefSeq: NP_001289736.1, NP_067048.4
Others	UniRef100: UniRef100_Q99935 UniRef90: UniRef90_Q99935 UniRef50: UniRef50_Q99935 UniGene: Hs.661425 CCDS: CCDS43235.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
27432908	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics Xu Li , Kim My Tran , Kathryn E Aziz , Alexey V Sorokin , Junjie Chen , Wenqi Wang	2016-09-01	-
24855109	Peptides in seminal fluid and their role in infertility: a potential role for opiorphin inhibition of neutral endopeptidase activity as a clinically relevant modulator of sperm motility: a review. Reprod Sci Jayme S Bosler , Kelvin P Davies , Genevieve S Neal-Perry	2014-11-01	OPRPN
24803544	Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells. FASEB J Shibo Fu , Moses Tarndie Tar , Arnold Melman , Kelvin Paul Davies	2014-08-01	-
25179084	Effects of synthetic analogues of human opiorphin on rat brain opioid receptors. J. Physiol. Pharmacol. Z Benyhe , G Toth , M Wollemann , A Borsodi , Z Helyes , C Rougeot , S Benyhe	2014-08-01	OPRPN
23580065	Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naÃ¯ve to therapy. Mol Biosyst Damiana Pieragostino , Luca Agnifili , Vincenzo Fasanella , Simona D'Aguanno , Rodolfo Mastropasqua , Carmine Di Ilio , Paolo Sacchetta , Andrea Urbani , Piero Del Boccio	2013-06-01	AKR1A1, SCGB1D1, CFL1, CFL2, CHEK1, PRR4, ZG16B, CST1, CST2, CST4, CSTB, CPNE9, EEF1A1P5, CFAP58, SUPT20HL2, EEF1A1, SERPINB1, ENO1, ALB, ALDOA, FRMD4B, UBN2, ATXN10, PRDX5, BLOC1S1, TIMM8B, RBMX, LCN1P1, GSTP1, ANXA1, HSPB1, IGHA1, IGHA2, IGHG1, IGHG2, IGHG3, IGHG4, JCHAIN, IGKC, IGLC1, IGLC2, IGLC3, IGLC6, KRT1, KRT2, KRT9, KRT10, KRT31, KRT33A, KRT33B, KRT34, KRT35, KRT81, KRT83, KRT85, KRT86, LCN1, LGALS3, LTF, LYZ, SCGB2A1, POTEE, OAS3, PRDX1, ESF1, SERPINA1, PIGR, PIP, PLA2G2A, BIVM, AZGP1, B2M, ACTA1, OPRPN, ACTA2, ACTB, S100A4, S100A9, S100A11, SH3BGRL, ZNF649, POTEI, POTEJ, TF, ACTC1, ACTG1, TPI1, C3, ACTG2, TST, POTEF, YWHAZ, KRT87P, LACRT, PRDX6
22664934	Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. Daniel BÃ¶hm , Ksenia Keller , Julia Pieter , Nils Boehm , Dominik Wolters , Wulf Siggelkow , Antje Lebrecht , Marcus Schmidt , Heinz KÃ¶lbl , Norbert Pfeiffer , Franz-Hermann Grus	2012-08-01	LOC101060157, USPL1, SCGB1D1, STAG3, MTHFD2, POP1, PRR4, ELFN2, MRGPRD, CLIC1, LRRK2, LRIG3, ZG16B, COL7A1, RBBP8NL, TTBK2, CST1, CST2, TMC8, CST4, DDB1, FREM3, DLG3, DMBT1, KRT78, ZFC3H1, SERPINB1, ENO1, ENO2, ENO3, ABCA3, ALB, ALDH3A1, CEP164, CNOT1, SIPA1L3, PMPCA, SULF1, KIAA0556, MCF2L, DMXL2, ZCCHC11, ALOX5, KLHL34, GNL3, KAT2A, MDGA1, GLE1, PRTG, LCN1P1, MRPL18, GSTP1, ANXA1, ANXA2, ANXA13, HP, HSPB1, APOA1, KLHL17, ACTBL2, IGHA1, IGHA2, IGHG2, IGHG3, IGHG4, JCHAIN, IGKC, IGLC1, IGLC2, MROH7, KRT1, KRT9, TRIM75P, LCN1, LCN2, LCP1, LGALS3, LOC400576, LTF, LYZ, MDH1, MECP2, SCGB2A1, MOV10, LOC439951, POTEE, ATP4A, PRDX1, PRKAG2, PDE4C, PIGR, PIP, PRKAG3, SEMA4C, LIME1, WDR60, NDUFAF7, ZNF446, SLF2
24900367	Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor. ACS Med Chem Lett Marta Pinto , Catherine Rougeot , Luis Gracia , MÃ²nica Rosa , AndrÃ©s GarcÃa , Gemma Arsequell , Gregorio Valencia , Nuria B Centeno	2012-01-12	OPRPN
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21624966	An update on analgesics. Br J Anaesth I Power	2011-07-01	-

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