| Type | Description |
|---|---|
| Definition | TBC1 domain family, member 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:27:00 | The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Into Skeletal Muscle via Transporter SLC27A4/FATP4. | 32868338 |
| 2020-05-30 12:18:00 | With increased glucose uptake and utilization involving AMPK-TBC1D1 signaling. | 31339770 |
| 2019-04-06 12:43:00 | The interaction enhances the efficiency by which AMPK phosphorylates TBC1D1 on its key regulatory site, Ser(237) Furthermore, the interaction is reduced by a naturally occurring R125W mutation in the PTB1 domain of TBC1D1, previously found to be associated with severe familial obesity in females, with a concomitant reduction in Ser(237) phosphorylation. | 30135087 |
| 2018-12-01 10:35:00 | Isolated pancreatic islets from D1KO mice exhibited substantially increased glucose-stimulated insulin secretion compared with controls.TBC1D1 exerts its function via a signaling pathway at the level of membrane depolarization. In line, ultrastructural analysis of isolated pancreatic islets revealed both higher insulin-granule density and number of docked granules in beta-cells from D1KO mice compared with WT controls. | 29481597 |
| 2018-01-20 11:09:00 | in obese leptin-deficient mice, lack of TBC1D1 has no impact on feeding behavior or energy intake but results in increased energy expenditure, altered energy substrate preference with increased fatty acid oxidation and suppression of obesity; TBC1D1 may have an evolutionary conserved role in regulating energy homeostasis in vertebrates | 27089993 |
| Type | IDs |
|---|---|
| Synonymous | 1110062G02Rik, AI385682, AW555803, Nob1, Nobq1, Tbc1, mKIAA1108 |
| Gene |
UniProtKB-ID:
TBCD1_MOUSE,
E9Q6L4_MOUSE,
Q3U3T9_MOUSE
UniprotKB:
Q60949,
E9Q6L4,
Q3U3T9
UniParc:
UPI000024E46D,
UPI00003569E8,
UPI0001611813
EMBL:
AC131679,
BC117931,
AC132271,
U33005,
AK154591,
AK122445,
BC004675
Ensembl:
ENSMUSG00000029174
KO:
mmu:57915
|
| Nucleutide sequences |
EMBL-CDS:
AAA85223.1,
AAH04675.1,
BAC65727.1,
AAI17932.1,
BAE32696.1
Ensembl_TRS:
ENSMUST00000101195,
ENSMUST00000043893,
ENSMUST00000121370,
ENSMUST00000119756
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000098756,
ENSMUSP00000112493,
ENSMUSP00000044577,
ENSMUSP00000113643
RefSeq:
XP_006504101.1,
XP_011239059.1,
XP_030110600.1,
NP_062610.2,
NP_001276443.1,
XP_011239061.1,
XP_036021280.1,
XP_036021279.1,
NP_001297540.1,
XP_006504100.1,
XP_011239060.1,
XP_006504099.1
|
| Others |
UniRef100:
UniRef100_Q60949,
UniRef100_E9Q6L4,
UniRef100_Q3U3T9
UniRef90:
UniRef90_D4AC16,
UniRef90_Q60949
UniRef50:
UniRef50_Q86TI0
UniGene:
Mm.286353
CCDS:
CCDS39094.1,
CCDS80287.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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