| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase receptor type A |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:42:00 | RPTPalpha phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. | 32139509 |
| 2020-05-16 12:44:00 | Filtered data from WES, combined with in silico analyses revealed a novel heterozygous missense variant (NM_080841:c.1730C>G:p.T577R; exon18) in Protein tyrosine phosphatase, receptor type A (PTPRA 20p13) in an Indian family with schizophrenia. Screening for variants in this gene in the WES data of an independent schizophrenia cohort (n=350) of matched ethnicity, identified five additional rare missense variants. | 30594456 |
| 2020-04-04 11:43:00 | Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cell adhesion molecules involved in mediating neuronal development. The binding of LAR-RPTPs to extracellular ligands induces local clustering of LAR-RPTPs to regulate axon growth and synaptogenesis. LAR-RPTPs interact with synaptic liprin-alpha proteins via the two cytoplasmic phosphatase domains, D1 and D2. | 31924785 |
| 2020-02-15 13:25:00 | miR-146a-5p may negatively regulate the PTPRA-SRC signaling to inhibit expression of fibrosis-related markers in irradiated and TGF-beta1-stimulated LX2 cells | 31560641 |
| 2020-02-08 11:25:00 | HePTP plays a key role in the metastasis of triple-negative breast cancer via activating Wnt/beta-catenin signaling. | 31545274 |
| Type | IDs |
|---|---|
| Synonymous | HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA |
| Gene |
UniProtKB-ID:
PTPRA_HUMAN
UniprotKB:
P18433
UniParc:
UPI00000012A8,
UPI000007155E
EMBL:
X54130,
BX571753,
AL121905,
CH471133,
X54890,
M34668,
BC027308,
X53364,
AK290233
Ensembl:
ENSG00000132670
KO:
hsa:5786
|
| Nucleutide sequences |
EMBL-CDS:
BAF82922.1,
AAA36528.1,
EAX10562.1,
CAE11878.1,
CAA37447.1,
CAA38065.1,
EAX10563.1,
CAA38662.1,
AAH27308.1
Ensembl_TRS:
ENST00000318266,
ENST00000216877,
ENST00000356147,
ENST00000399903,
ENST00000380393
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000348468,
ENSP00000216877,
ENSP00000382787,
ENSP00000369756,
ENSP00000314568
RefSeq:
NP_001372249.1,
NP_001372234.1,
NP_001372250.1,
NP_001375253.1,
NP_001372233.1,
NP_001372231.1,
NP_001372248.1,
NP_001372235.1,
NP_001372232.1,
NP_001372236.1,
NP_001372242.1,
NP_001375251.1,
NP_543031.1,
NP_001372237.1,
NP_001372245.1,
NP_001372241.1,
NP_001372239.1,
NP_001375252.1,
NP_002827.1,
NP_001372243.1,
NP_543030.1,
NP_001372247.1,
NP_001372240.1,
NP_001372246.1,
NP_001372244.1
|
| Others |
UniRef100:
UniRef100_P18433
UniRef90:
UniRef90_P18433
UniRef50:
UniRef50_P18052-2
UniGene:
Hs.269577
CCDS:
CCDS13038.1,
CCDS13039.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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