| Type | Description |
|---|---|
| Definition | hes family bHLH transcription factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2017-07-01 12:05:00 | Hes4 overexpression promotes a more aggressive tumor phenotype by preventing osteoblastic differentiation of osteosarcoma cells. Hes4 expression may allow for the stratification of patients into good or poor responders to chemotherapy at diagnosis. | 27786411 |
| 2016-02-20 10:20:00 | Overexpression and knockdown studies demonstrated that Hes4 promotes osteogenesis resulting in an increase in Runx2, osteocalcin, osteopontin, and bone sialoprotein expression in BMSC. | 25579220 |
| 2015-11-21 10:52:00 | Epigenetic dysregulation of HES4 could play a critical role in modifying Huntington's disease pathogenesis and severity. | 25480889 |
| Type | IDs |
|---|---|
| Synonymous | bHLHb42 |
| Gene |
UniProtKB-ID:
HES4_HUMAN,
D6REB3_HUMAN,
E9PB28_HUMAN
UniprotKB:
Q9HCC6,
D6REB3,
E9PB28
UniParc:
UPI000006EC19,
UPI0001881B51,
UPI0001D3BBEE
EMBL:
BC012351,
AB048791,
AL645608
Ensembl:
ENSG00000188290
KO:
hsa:57801
|
| Nucleutide sequences |
EMBL-CDS:
AAH12351.1,
BAB13510.1
Ensembl_TRS:
ENST00000304952,
ENST00000484667,
ENST00000428771
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000304595,
ENSP00000425085,
ENSP00000393198
RefSeq:
NP_066993.1,
NP_001135939.1,
XP_005244828.1
|
| Others |
UniRef100:
UniRef100_D6REB3,
UniRef100_E9PB28,
UniRef100_Q9HCC6
UniRef90:
UniRef90_E9PB28,
UniRef90_Q9HCC6,
UniRef90_A0A2K5RL89
UniRef50:
UniRef50_K7G8M5,
UniRef50_Q9HCC6
UniGene:
Hs.154029
CCDS:
CCDS5.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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