| Type | Description |
|---|---|
| Definition | spen family transcription repressor |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:27:00 | Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation. | 32379046 |
| 2020-11-21 13:28:00 | Elements at the 5' end of Xist harbor SPEN-independent transcriptional antiterminator activity. | 32986830 |
| 2020-05-30 12:33:00 | SPEN is a key orchestrator of X-chromosome inactivation (XCI) in vivo and its mechanism of action is elucidated; SPEN acts as a molecular integrator for the initiation of XCI, bridging Xist RNA with the transcription machinery--as well as with nucleosome remodellers and histone deacetylases-at active enhancers and promoters | 32025035 |
| 2020-03-07 12:29:00 | Structural and Functional Studies of the Complex Reveal a Conserved Corepressor Binding Site. | 30673607 |
| 2017-07-22 10:57:00 | Spenito, a small Spen family member, counteracted Spen function in fat regulation. Finally, mouse Spen and Spenito transcript levels scaled directly with body fat in vivo, suggesting a conserved role in fat liberation and catabolism. This study demonstrates that Spen is a key regulator of energy balance and provides a molecular context to understand the metabolic defects that arise from Spen dysfunction. | 28640815 |
| Type | IDs |
|---|---|
| Synonymous | Mint, mKIAA0929 |
| Gene |
UniProtKB-ID:
MINT_MOUSE,
A2ADB0_MOUSE,
A2ADB1_MOUSE,
Q3UV27_MOUSE
UniprotKB:
Q62504,
A2ADB0,
A2ADB1,
Q3UV27
UniParc:
UPI0000435308,
UPI00001D8A6D,
UPI00001D8A6C,
UPI00005ABDA9,
UPI000024E20B,
UPI000050D3B6
EMBL:
AF156529,
AL670285,
BY726481,
Z78160,
AB055980,
AK122402,
AL670446,
AK137647
Ensembl:
ENSMUSG00000040761
KO:
mmu:56381
|
| Nucleutide sequences |
EMBL-CDS:
BAB32786.1,
BAC65684.3,
CAB01562.1,
AAD55931.1,
BAE23446.1
Ensembl_TRS:
ENSMUST00000105786,
ENSMUST00000078886
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000101412,
ENSMUSP00000077925
RefSeq:
NP_062737.2,
XP_006539133.1,
XP_036020160.1,
XP_006539136.1,
XP_036020161.1,
XP_036020159.1,
NP_001334164.1,
XP_006539132.1
|
| Others |
UniRef100:
UniRef100_Q3UV27,
UniRef100_Q62504,
UniRef100_A2ADB1,
UniRef100_A2ADB0
UniRef90:
UniRef90_A2ADB0,
UniRef90_Q62504,
UniRef90_G3VR73
UniRef50:
UniRef50_G3VR73,
UniRef50_Q96T58
UniGene:
Mm.299906
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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