| Type | Description |
|---|---|
| Definition | hypoxia inducible factor 1 subunit alpha inhibitor |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 10:39:00 | Authors provide evidence, based on the application of genetic interventions and small molecule inhibition of the HIF hydroxylases, that the nuclear localization of FIH is governed by two opposing processes: nuclear entry by 'coupling' with HIF1alpha for importin beta1-mediated nuclear import and active export via a Leptomycin B-sensitive exportin1-dependent pathway. | 30333145 |
| 2019-07-13 13:01:00 | Low FIH expression is associated with lung cancer. | 30004795 |
| 2019-03-16 12:26:00 | ANKDD1A directly interacts with FIH1 and inhibits the transcriptional activity of HIF1alpha by upregulating FIH1. ANKDD1A decreases the half-life of HIF1alpha by upregulating FIH1, decreases glucose uptake and lactate production, inhibits glioblastoma multiforme (GBM) autophagy, and induces apoptosis in GBM cells under hypoxia | 30082910 |
| 2019-01-19 11:49:00 | High FIH expression is associated with Ovarian Cancer metastasis. | 29259012 |
| 2019-01-12 11:56:00 | FIH-1 plasmid transfection decreased the cell proliferation of OS-RC-2 renal carcinoma cells,but did not show inhibition on 786-0 cell proliferation | 29737085 |
| Type | IDs |
|---|---|
| Synonymous | FIH1 |
| Gene |
UniProtKB-ID:
HIF1N_HUMAN
UniprotKB:
Q9NWT6
UniParc:
UPI000006D2A7
EMBL:
AL359615,
CH471066,
AK000622,
BC007719,
AF395830,
AL133352
Ensembl:
ENSG00000166135
KO:
hsa:55662
|
| Nucleutide sequences |
EMBL-CDS:
EAW49818.1,
AAH07719.1,
BAA91291.1,
CAB94885.1,
EAW49817.1,
AAL27308.1
Ensembl_TRS:
ENST00000299163
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000299163
RefSeq:
XP_011538243.1,
NP_060372.2,
XP_011538242.1
|
| Others |
UniRef100:
UniRef100_Q9NWT6
UniRef90:
UniRef90_Q9NWT6
UniRef50:
UniRef50_Q9NWT6
UniGene:
Hs.500788
CCDS:
CCDS7498.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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