| Type | Description |
|---|---|
| Definition | XIAP associated factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:12:00 | Paradoxical epigenetic regulation of XAF1 mediates plasticity towards adaptive resistance evolution in MGMT-methylated glioblastoma. | 31575897 |
| 2019-12-07 10:14:00 | XAF1 enhances IRF-1-mediated transcription of proapoptotic genes via the XAF1-IRF-1 complex formation on these target promoters. XAF1 inhibits NF-kappaB-mediated tumor cell malignancy by reinforcing IRF-1 binding to a subset of coregulated promoters. | 30042418 |
| 2019-09-21 10:24:00 | Results support a model in which YY1 is able to silence tumor suppressor genes such as XAF1 through HDAC1 in prostate cancer. | 30551877 |
| 2019-08-31 10:22:00 | Results found that XAF1 transcription levels are downregulated in colorectal neoplasm cells by TGFB1 which activates RAS-ERK signaling. | 31081052 |
| 2018-05-19 10:45:00 | this study uncovers an important role for XAF1-MT2A antagonism as a linchpin to govern cell fate under various stressful conditions including heavy metal exposure. | 28507149 |
| Type | IDs |
|---|---|
| Synonymous | BIRC4BP, HSXIAPAF1, XIAPAF1 |
| Gene |
UniProtKB-ID:
XAF1_HUMAN
UniprotKB:
Q6GPH4
UniParc:
UPI000170BA6F,
UPI000170BA70,
UPI0000F08866,
UPI0000F08865,
UPI0000200793,
UPI00015DA5AD,
UPI000020078D
EMBL:
CH471108,
X99699,
BC073156,
BX649188,
AK290276,
BC032776,
AK292710,
AK292848,
EF028166,
EF028165
Ensembl:
ENSG00000132530
KO:
hsa:54739
|
| Nucleutide sequences |
EMBL-CDS:
CAE46206.1,
BAF85399.1,
CAA68030.1,
EAW90288.1,
ABM74557.1,
ABM74556.1,
AAH73156.1,
BAF82965.1,
BAF85537.1,
EAW90289.1,
AAH32776.1
Ensembl_TRS:
ENST00000361842,
ENST00000574962,
ENST00000571673,
ENST00000346752
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000354822,
ENSP00000461196,
ENSP00000458229,
ENSP00000341029
RefSeq:
XP_024306578.1,
XP_011522247.1,
NP_001340065.1,
NP_001340069.1,
NP_001340068.1,
NP_001340066.1,
XP_024306577.1,
XP_005256763.1,
NP_001340067.1,
XP_011522251.1,
XP_005256765.1,
NP_059993.2,
XP_011522250.1,
NP_001340063.1,
NP_001340064.1,
NP_954590.1
|
| Others |
UniRef100:
UniRef100_Q6GPH4
UniRef90:
UniRef90_Q6GPH4
UniRef50:
UniRef50_Q6GPH4
UniGene:
Hs.441975
CCDS:
CCDS11080.1,
CCDS11081.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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