Identification of XAF1-MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions.

Proc. Natl. Acad. Sci. U.S.A.2017 May 30;114(22):5683-5688. Epub 2017 May 15

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cells. Clinically, expression levels of XAF1 and MT2A are inversely correlated in primary colon tumors and multiple cancer cell lines. XAF1-depleted xenograft tumors display an increased growth rate and a decreased apoptotic response to cytotoxic heavy metals with strong MT2A expression. Collectively, this study uncovers an important role for XAF1-MT2A antagonism as a linchpin to govern cell fate under various stressful conditions including heavy metal exposure.

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Identification of XAF1-MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions.

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