WDR74 functions as a novel coactivator in TGF-Î² signaling.

J Genet Genomics. 2018 Dec 20;45(12):639-650. Epub 2018 Nov 27

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摘要

Smads are critical intracellular signal transducers for transforming growth factor-Î² (TGF-Î²) in mammalian cells. In this study, we have identified WD repeat-containing protein 74 (WDR74) as a novel transcriptional coactivator for Smads in the canonical TGF-Î² signaling pathway. Through direct interactions with Smad proteins, WDR74 enhances TGF-Î²-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3. Consequently, WDR74 enables stronger transcriptional responses and more robust TGF-Î²-induced physiological responses. Our findings have elucidated a critical role of WDR74 in regulating TGF-Î² signaling.

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WDR74 functions as a novel coactivator in TGF-Î² signaling.

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