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5187 PER1

5187

PER1

period circadian regulator 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition period circadian regulator 1

研究结论

Date Results Publications
2020-08-15 19:08:00 PER1 rs3027188 Polymorphism and its Association with the Risk of Colorectal Cancer in the Japanese Population. 32541172
2020-06-06 13:37:00 The clock gene Period 1 (Per1) is downregulated in oral squamous cell carcinoma (OSCC) and low Per1 expression is associated with TNM clinical stage and poor prognosis of OSCC patients. Per1 promotes OSCC progression by inhibiting autophagy-mediated cell apoptosis and enhancing cell proliferation in an AKT/mTOR pathway-dependent manner. 32086839
2020-01-18 11:30:00 Study reported an association between the risk of prostate cancer and the circadian pathway where significant associations were found for the genes NPAS2 and PER1. 30665264
2019-10-26 12:07:00 A two-way ANOVA revealed significant differences between the clock genes profiles of controls and RBD patients for hPer1 (P = 0.0324), hPer2 (P = 0.0039), hBmal1 (P = 0.0160), and hNr1d1 (P = 0.0046). 30195196
2019-09-21 11:43:00 These data together suggest that Per-1 is a novel negative regulator of HIV-1 transcription. This restrictive activity of Per-1 to HIV-1 replication may contribute to HIV-1 latency in resting CD4+ T-cells. 30774045

名称对应

Type IDs
Synonymous PER, RIGUI, hPER
Gene
UniProtKB-ID: PER1_HUMAN
UniprotKB: O15534
UniParc: UPI00017A71C2, UPI000013FFF5
EMBL: AF102137, AB088477, CH471108, AF022991, BC137346, AC129492, AB030817, AB002107, AK295410
Ensembl: ENSG00000179094
KO: hsa:5187
Nucleutide sequences
EMBL-CDS: AAI37347.1, EAW90091.1, BAA94085.1, AAC51765.1, AAF15544.1, BAG58361.1, BAA22633.1, BAC06326.2, EAW90090.1
Ensembl_TRS: ENST00000317276, ENST00000354903
Protein sequencees
Ensembl_PRO: ENSP00000346979, ENSP00000314420
RefSeq: XP_005256747.1, NP_002607.2, XP_005256746.1, XP_024306571.1
Others
UniRef100: UniRef100_O15534
UniRef90: UniRef90_O15534
UniRef50: UniRef50_O15534
UniGene: Hs.445534
CCDS: CCDS11131.1

全选

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