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Circadian rhythms of melatonin and peripheral clock gene expression in idiopathic REM sleep behavior disorder.

Sleep Med.2018 Dec;52:1-6. Epub 2018 Aug 09
Kamila Weissová 1 , Jitka Škrabalová 1 , Kateřina Skálová 2 , Kateřina Červená 2 , Zdeňka Bendová 1 , Eva Miletínová 3 , Jana Kopřivová 4 , Karel Šonka 5 , Daniela Dudysová 3 , Aleš Bartoš 4 , Jitka Bušková 6
Kamila Weissová 1 , Jitka Škrabalová 1 , Kateřina Skálová 2 , Kateřina Červená 2 , Zdeňka Bendová 1 , Eva Miletínová 3 , Jana Kopřivová 4 , Karel Šonka 5 , Daniela Dudysová 3 , Aleš Bartoš 4 , Jitka Bušková 6
+ et al

[No authors listed]

Author information
  • 1 National Institute of Mental Health, Klecany, Czech Republic; Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic.
  • 2 Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic.
  • 3 National Institute of Mental Health, Klecany, Czech Republic.
  • 4 National Institute of Mental Health, Klecany, Czech Republic; Third Faculty of Medicine, Charles University, Prague, Czech Republic.
  • 5 Department of Neurology and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • 6 National Institute of Mental Health, Klecany, Czech Republic; Third Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: vankjit@seznam.cz.

摘要


OBJECTIVE:To evaluate changes in the expression of clock genes and melatonin levels in patients with idiopathic REM sleep behavior disorder (RBD) as a potential early stage of synucleinopathies. METHODS:We assessed the rhythmicity of circadian clock genes using real time-quantitative polymerase chain reaction and 24-h blood melatonin profiles using radio-immunoassay in 10 RBD patients and nine age-matched controls. RESULTS:The RBD patients did not show circadian rhythmicity for clock genes Per2, Bmal1, and Nr1d1 but the rhythmicity of Per 1 remained, and the amplitude of Per3 was diminished. The 24-h melatonin rhythm did not differ between RBD patients and healthy control subjects. Melatonin profile in RBD patients was delayed by 2 h compared to controls, the habitual sleep phases were phase delayed by about 1 h, however no phase shift occurred in any of the clock genes studied. The control group had stable acrophases of melatonin rhythms of approximately 5 h whereas the RBD patients had a more dispersed range over 11 h. CONCLUSIONS:Our results suggest that RBD could be associated with altered expression of clock genes and delayed melatonin secretion. Thus, we argue that circadian system dysregulation could play a role in RBD.

KEYWORDS: Clock genes expression, Idiopathic rapid eye movement sleep (REM) sleep behavior disorder, Melatonin