| Type | Description |
|---|---|
| Definition | denticleless E3 ubiquitin protein ligase homolog |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 12:23:00 | The rs11275300:G allele in the 3'UTR of DTL may lead to a poor prognosis and allele-specific increase in the expression of DTL by post-transcriptional regulation in acral melanoma. | 31325875 |
| 2020-01-18 11:10:00 | Our results elucidated that DTL enhanced the motility and proliferation of cancer cells through degrading PDCD4 to promote the development of cancers. | 31409387 |
| 2019-08-03 10:12:00 | As the ligase activity of CRL4Cdt2 depends on proliferating cell nuclear antigen (PCNA) loading onto DNA, the present results suggest that the DNA-binding domain facilitates the CRL4Cdt2-mediated recognition and ubiquitination of substrates bound to PCNA on chromatin. | 30649446 |
| 2019-04-20 10:49:00 | CDT2 has a PIP box-like motif at its C terminus. This motif directly interacts with PCNA to help promote degradation of CDT1 during replication or in response to DNA damage. | 30301766 |
| 2018-09-29 11:53:00 | Results suggest that CDK-mediated phosphorylation of Cdt2 inactivates its ubiquitin ligase activity by reducing its affinity to PCNA, an important strategy for regulating the levels of key proteins in the cell cycle. | 29424068 |
| Type | IDs |
|---|---|
| Synonymous | CDT2, DCAF2, L2DTL, RAMP |
| Gene |
UniProtKB-ID:
DTL_HUMAN,
B4E0E6_HUMAN
UniprotKB:
Q9NZJ0,
B4E0E6
UniParc:
UPI00017A84D2,
UPI000006E98C,
UPI000013E1C1
EMBL:
AF345896,
AK001206,
AK001261,
AL606468,
AC092814,
AF195765,
BC033297,
AK292343,
BC033540,
AK303346,
CH471100,
AL592297,
DQ641253,
AK000742,
AK027651
Ensembl:
ENSG00000143476
KO:
hsa:51514
|
| Nucleutide sequences |
EMBL-CDS:
BAA91355.1,
BAF85032.1,
AAF35182.1,
AAH33297.1,
BAA91586.1,
ABG23317.1,
AAK54706.1,
BAA91552.1,
AAH33540.1,
EAW93397.1,
BAB55267.1,
EAW93395.1,
BAG64408.1
Ensembl_TRS:
ENST00000366991
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000355958
RefSeq:
NP_001273159.2,
NP_057532.4,
NP_001273158.2,
XP_011507916.1
|
| Others |
UniRef100:
UniRef100_B4E0E6,
UniRef100_Q9NZJ0
UniRef90:
UniRef90_Q9NZJ0
UniRef50:
UniRef50_Q9NZJ0
UniGene:
Hs.656473
CCDS:
CCDS1502.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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