for PCNA and its ubiquitination activity in S phase.
Genes Cells. 2018 Mar;23(3):200-213. doi:10.1111/gtc.12563. Epub 2018 Feb 09
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摘要
substrates, Set8 and thymine DNA glycosylase, begin to accumulate around late S phase to G2 phase, but the accumulation was prevented in Cdt2-18A cells. Furthermore, mitotic degradation of Cdt1 after UV irradiation was induced in these cells. Our results suggest that CDK-mediated phosphorylation of Cdt2 inactivates its ubiquitin ligase activity by reducing its affinity to PCNA, an important strategy for regulating the levels of key proteins in the cell cycle.
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基因功能
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原始数据
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文献解读
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