MECR - mitochondrial trans-2-enoyl-CoA reductase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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51102 MECR

基因描述

Type	Description
Definition	mitochondrial trans-2-enoyl-CoA reductase

研究结论

Date	Results	Publications
2017-12-30 12:46:00	MECR is involved in mitochondrial fatty acid synthesis, and overexpression of this gene increases peroxisome proliferator-activated receptor alpha (PPARalpha) activity.	27845578
2017-05-27 12:08:00	results suggest that mutations in MECR cause a distinct human disorder of the mitochondrial fatty acid synthesis pathway; the observation of decreased lipoylation raises the possibility of a potential therapeutic strategy	27817865
2014-01-18 11:14:00	overexpression of MECR, the last step in the mitochondrial fatty acid synthesis (mtFASII) pathway, causes modulation of gene expression through the PPAR pathway.	24161390
2010-12-05 22:08:00	Observational study of gene-disease association. (HuGE Navigator)	20877624
2010-01-21 00:00:00	The crystal structure of this dimeric enzyme (at 2.4 A resolution) suggests that the binding site for the recognition helix of the acyl carrier protein is in a groove between the two adjacent monomers.	18479707

名称对应

Type	IDs
Synonymous	CGI-63, DYTOABG, ETR1, FASN2B, NRBF1
Gene	UniProtKB-ID: MECR_HUMAN UniprotKB: Q9BV79 UniParc: UPI000013D444, UPI00004701B4 EMBL: AL590729, CH471059, AF151821, BC001419, AK095099, CR456703 Ensembl: ENSG00000116353 KO: hsa:51102
Nucleutide sequences	EMBL-CDS: BAG52984.1, AAH01419.1, EAX07655.1, CAG32984.1, AAD34058.1 Gene_ORFName: CGI-63 Ensembl_TRS: ENST00000263702, ENST00000373791
Protein sequencees	Ensembl_PRO: ENSP00000263702, ENSP00000362896 RefSeq: XP_011539843.1, XP_011539848.1, XP_011539849.1, NP_001336646.1, NP_001019903.3, XP_016856900.1, NP_001336644.1, XP_024303216.1, XP_016856905.1, XP_024303211.1, XP_011539856.1, XP_016856902.1, XP_011539845.1, NP_057095.4, NP_001336640.1, XP_011539841.1, XP_024303214.1, NP_001336642.1, XP_016856901.1, XP_011539842.1, XP_024303212.1, XP_011539855.1, NP_001336641.1, XP_024303210.1, XP_011539847.1, XP_011539852.1, NP_001336643.1, XP_024303220.1, XP_011539851.1, NP_001336645.1, XP_024303218.1
Others	UniRef100: UniRef100_Q9BV79 UniRef90: UniRef90_Q9BV79 UniRef50: UniRef50_Q9BV79 UniGene: Hs.183646 CCDS: CCDS30660.1, CCDS30659.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
28700943	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Rep Timothy D Martin , Danielle R Cook , Mei Yuk Choi , Mamie Z Li , Kevin M Haigis , Stephen J Elledge	2017-07-11	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
27817865	MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder. Am. J. Hum. Genet. Gali Heimer , Juha M KerÃ¤tÃ¤r , Lisa G Riley , Shanti Balasubramaniam , Eran Eyal , Laura P PietikÃ¤inen , J Kalervo Hiltunen , Dina Marek-Yagel , Jeffrey Hamada , Allison Gregory , Caleb Rogers , Penelope Hogarth , Martha A Nance , Nechama Shalva , Alvit Veber , Michal Tzadok , Andreea Nissenkorn , Davide Tonduti , Florence Renaldo , University of Washington Center for Mendelian Genomics , Ichraf Kraoua , Celeste Panteghini , Lorella Valletta , Barbara Garavaglia , Mark J Cowley , Velimir Gayevskiy , Tony Roscioli , Jonathon M Silberstein , Chen Hoffmann , Annick Raas-Rothschild , Valeria Tiranti , Yair Anikster , John Christodoulou , Alexander J Kastaniotis , Bruria Ben-Zeev , Susan J Hayflick	2016-12-01	-
27845578	The Well-Known Gene HHIP and Novel Gene MECR Are Implicated in Small Airway Obstruction. Am. J. Respir. Crit. Care Med. Diana A van der Plaat , Kim de Jong , Lies Lahousse , Alen Faiz , Judith M Vonk , Cleo C van Diemen , Ivana Nedeljkovic , Najaf Amin , Ma'en Obeidat , Cornelia M van Duijn , H Marike Boezen , Dirkje S Postma	2016-11-15	-
26496610	A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , JÃ¼rgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , JÃ¶rg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann	2015-10-22	Cep85l, Rcc1, Zbtb48, Bsdc1, Kifc1, Ccp110, Ints4, Slc6a8, Cenpi, Nup107, Xpo1, Fbxw11, Tubg1, Csnk1d, Bap1, Ptpn23, Tecpr2, Slain1, Ankrd28, Prkaa1, Espl1, Gbf1, Cdc20, Cenpf, Trip11, Mbd5, Kif22, Dut, Srsf1, Actb, Spred2, Akt2, Mta1, Tgs1, Pip4k2c, Ankfy1, Apc, Ar, Rhoa, Atp2a2, Atp5a1, Atp7a, Cep131, Bach1, Bcl7c, Bmpr1a, Brca1, Bub1, Bub1b, C1qbp, Anxa2, Calu, Cbx1, Cbx4, Cct2, Cct3, Cct4, Cct7, Cct8, Cd2ap, Cdk1, Cdc37, Cdh1, Chek1, Cit, Copa, Crebbp, Cry1, Csk, Smc3, Dctn1, Ddb1, Cdk2ap1, Mapre1, Ect2, Eef1a1, Eif3a, Mark2, Evpl, Ewsr1, Wdr5, Dclre1b, Fbl, Fgfr1, Flot1, Flot2, B4galt1, Gnb1, Gspt1, Hdac6, Herc2, Hsf1, Hsph1, Elavl1, Id2, Cyr61, Cep250, Insr, Eif3e
26344197	Panorama of ancient metazoan macromolecular complexes. Nature Cuihong Wan , Blake Borgeson , Sadhna Phanse , Fan Tu , Kevin Drew , Greg Clark , Xuejian Xiong , Olga Kagan , Julian Kwan , Alexandr Bezginov , Kyle Chessman , Swati Pal , Graham Cromar , Ophelia Papoulas , Zuyao Ni , Daniel R Boutz , Snejana Stoilova , Pierre C Havugimana , Xinghua Guo , Ramy H Malty , Mihail Sarov , Jack Greenblatt , Mohan Babu , W Brent Derry , Elisabeth R Tillier , John B Wallingford , John Parkinson , Edward M Marcotte , Andrew Emili	2015-09-17	AKT3, MED6, ABI1, GNPDA1, SRA1, TDRD15, HMGN1P30, PDCD6IP, PDCD6, MED16, ADA, CHAF1A, TOM1, RANBP9, SMC4, ARPC4-TTLL3, RBM14-RBM4, RNF103-CHMP3, CHURC1-FNTB, AP1M2, ISY1-RAB43, UBA2, SAE1, FARSB, DNM1L, ABCF2, COX17, SCAMP2, SCAMP3, DPP3, SNUPN, HUWE1, TSSC4, ATP9A, PQBP1, COL4A3BP, PTGES3L-AARSD1, ARPC5, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, NUBP2, PPIF, LOC101060521, ARPC2, RAD50, ACTR1B, ACTR1A, ADAM8, LRPPRC, PDIA6, TRAP1, BCAP31, NAMPT, RBM12, G3BP1, ABI2, CEBPZ, TRIM28, AASS, ATP6AP2, WASF2, SLC25A13, CDK2, RBM7, ALYREF, TXNDC9, LOC101929876, PSME3, MPHOSPH10, MPHOSPH6, CDK5, NUTF2, EIF1, DDX39A, PSMD14, CDK7, PLIN3, HNRNPR, MRPS31, CDK8, RABEPK, RIDA, SRRM1, CDK9, STAM2, SF3B4, ZMPSTE24, AKAP8, STUB1, STAG1, UBE4B, PRSS16, SIGMAR1, BET1, CWC27, SAP18
26186194	The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin WÃ¼hr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi	2015-07-16	-
24161390	The mitochondrial fatty acid synthesis (mtFASII) pathway is capable of mediating nuclear-mitochondrial cross talk through the PPAR system of transcriptional activation. Biochem. Biophys. Res. Commun. Angelika Parl , Sabrina L Mitchell , Hayley B Clay , Sara Reiss , Zhen Li , Deborah G Murdock	2013-11-15	MECR
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell Alfredo Castello , Bernd Fischer , Katrin Eichelbaum , Rastislav Horos , Benedikt M Beckmann , Claudia Strein , Norman E Davey , David T Humphreys , Thomas Preiss , Lars M Steinmetz , Jeroen Krijgsveld , Matthias W Hentze	2012-06-08	GNPDA1, SCARNA27, GABPB1-AS1, NFYC-AS1, FKSG29, PHKA2-AS1, HDAC6, PDCD6, C17orf96, LOC100287042, MIR3652, ARPC4-TTLL3, ATP5J2-PTCD1, TGIF2-C20orf24, FARSB, ABCC5, ABCF2, HUWE1, ARPC4, ARPC1B, ACTR3, ACTR1A, LRPPRC, TRAP1, BCAP31, NAMPT, RBM12, TOB1, G3BP1, SUGP2, MBNL2, ABI2, CEBPZ, ATP6AP2, SLC25A15, RCL1, RBM7, RBM6, RBM5, ALYREF, PSME3, MPHOSPH10, NUTF2, USPL1, DDX39A, STX6, HNRNPR, MRPS31, RIDA, SF3B4, AKAP8, STUB1, SIGMAR1, SMNDC1, BCAS2, SF3A1, CDKN2A, APBB3, SMYD5, ADAR, EMC8, NPM3, HMG20A, NOD1, RACK1, NDC80, NSA2, YAP1, CD2BP2, TUBGCP3, RBM14, EMG1, ACAA2, PPIE, TAB1, MAD2L2, PIBF1, SLC25A17, NXF1, CREB3, LRRC41, SYNCRIP, ENOX2, MYBBP1A, DDX17, ADARB2, CHERP, HYOU1, IPO8, NOP56, RNASEH2A, GLRX3, DCTN2, LAMTOR5, PRDX4, AGPAT1, RPP30, SLU7, MRPL28
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-

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