| Type | Description |
|---|---|
| Definition | par-6 family cell polarity regulator alpha |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:31:00 | A polybasic domain in mediates Par6-dependent control of membrane targeting and kinase activity. | 32580209 |
| 2020-07-11 11:39:00 | The pathological analysis confirmed the correlation between Par6 expression and the prognosis in human glioma tissues, suggesting the regulation of Par6 expression regulates glioma tumorigenesis and progression. | 31914615 |
| 2019-04-27 11:30:00 | In Par6A knockout cells, we find that active Cdc42 is more mobile at the apical membrane compared to control cells and that wild type Cdc42 is more diffusely localized throughout the cell, indicating that Par6A is required to restrict Cdc42 signaling. | 30408122 |
| 2018-11-24 11:38:00 | In T84 cells, overexpression of Par-6 causes intestinal barrier dysfunction. Lipopolysaccharide (LPS)-induced intestinal epithelial barrier dysfunction and increase in Par-6 expression was prevented by AhR activation. | 29992488 |
| 2018-11-03 10:20:00 | Studies indicate that the complex are important for the establishment of neuronal polarity [Review]. | 29696344 |
| Type | IDs |
|---|---|
| Synonymous | PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40 |
| Gene |
UniProtKB-ID:
PAR6A_HUMAN
UniprotKB:
Q9NPB6
UniParc:
UPI000006F1C0,
UPI0000070183
EMBL:
AJ277095,
AB043634,
AF028827,
BC015626,
AF252292,
AF265565,
AB041642
Ensembl:
ENSG00000102981
KO:
hsa:50855
|
| Nucleutide sequences |
EMBL-CDS:
AAF71529.1,
CAB85490.1,
BAA96235.1,
AAF75548.1,
AAH15626.1,
AAB84252.1,
BAB16105.1
Ensembl_TRS:
ENST00000219255,
ENST00000458121
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000392388,
ENSP00000219255
RefSeq:
XP_011521397.1,
XP_005256034.1,
NP_058644.1,
NP_001032358.1
|
| Others |
UniRef100:
UniRef100_Q9NPB6
UniRef90:
UniRef90_Q9NPB6
UniRef50:
UniRef50_Q9NPB6
UniGene:
Hs.112933
CCDS:
CCDS45514.1,
CCDS10843.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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