PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.

Polarity is a fundamental feature of cells. Protein complexes, including the complex, have conserved roles in establishing polarity across a number of eukaryotic cell types. In neurons, polarity is evident as distinct axonal versus dendritic domains. The PAR3, PAR6, and proteins also play important roles in neuronal polarization. During this process, either aduanyu1531 kinase activity, the assembly of the PAR3-PAR6-aduanyu1531 complex or the localization of these proteins is regulated downstream of a number of signaling pathways. In turn, the PAR3, PAR6, and aduanyu1531 proteins control various effector molecules to establish neuronal polarity. Herein, we discuss the many signaling mechanisms and effector functions that have been linked to PAR3, PAR6, and aduanyu1531 during the establishment of neuronal polarity.

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