| Type | Description |
|---|---|
| Definition | survival motor neuron |
| Date | Results | Publications |
|---|---|---|
| 2019-01-12 12:00:00 | SCFSlmb interacts with a phosphor degron embedded within the human and fruitfly SMN YG-box oligomerization domains. Substitution of a conserved serine (S270A) interferes with SCFSlmb binding and stabilizes SMNDelta7. Spinal muscular atrophy (SMA)-causing missense mutations that block multimerization of full-length SMN are also stabilized in the degron mutant background. | 29167380 |
| 2018-10-20 12:21:00 | Role of SMN in oogenesis: key requirement for mRNA trafficking. | 29895323 |
| 2015-11-21 10:26:00 | Intragenic complementation analyses reveal the potential for dominant negative interactions between wild-type and mutant SMN subunits, highlighting the essential nature of the YG box in formation of higher-order SMN multimers. | 25144193 |
| 2013-12-21 11:26:00 | Smn mutants displayed a prominent increase in levels of stress-responsive transcripts, indicating a systemic response to the developmental arrest induced by loss of SMN protein | 24006466 |
| 2013-09-07 11:56:00 | A unique interactome for SMN provides a knowledge base for a better understanding of spinal muscular atrophy. | 23757500 |
| Type | IDs |
|---|---|
| Synonymous | CG16725, DmSMN, Dmel\CG16725, SMN, dSMN, l(3)73Ao, smn |
| Gene |
UniProtKB-ID:
SMN_DROME
UniprotKB:
Q9VV74
UniParc:
UPI000007843F
EMBL:
AF296281,
AY058529,
AE014296
EnsemblGenome:
FBgn0036641
KO:
dme:Dmel_CG16725
|
| Nucleutide sequences |
EMBL-CDS:
AAF49446.1,
AGB94647.1,
AAG17893.1,
AAL13758.1
Gene_ORFName:
CG16725
EnsemblGenome_TRS:
FBtr0329921,
FBtr0075395
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0075153,
FBpp0302954
RefSeq:
NP_001261954.1,
NP_524112.1
|
| Others |
UniRef100:
UniRef100_Q9VV74
UniRef90:
UniRef90_Q9VV74
UniRef50:
UniRef50_Q9VV74
UniGene:
Dm.2679
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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