| Type | Description |
|---|---|
| Definition | downstream of receptor kinase |
| Date | Results | Publications |
|---|---|---|
| 2014-11-29 10:53:00 | identifies DRK/DOS/SOS as the upstream Rac GEF complex required for glial responses to axonal injury, and demonstrates a critical requirement for multiple GEFs in efficient glial activation after injury and internalization/degradation of axonal debris | 25099352 |
| 2011-09-03 11:01:00 | Drk plays a negative role in EGFR signaling by enhancing receptor endocytosis through cooperating with the RING domain of D-Cbl. | 21340027 |
| 2010-01-21 00:00:00 | SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases. | 12128212 |
| 2010-01-21 00:00:00 | Structural characterizations of the drkN SH3 domain unfolded state. | 17320108 |
| 2010-01-21 00:00:00 | Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1). | 12673197 |
| Type | IDs |
|---|---|
| Synonymous | 24/1, CG6033, DRK, Dmel\CG6033, Drk, Drk/Grb2, E(sev)2B, GRB2, Grb-2, Grb/drk, Grb2, Grb2/drk, P1112, Su(sev)R1, crkl, l(2)10626, l(2)k13809 |
| Gene |
UniProtKB-ID:
GRAP_DROME
UniprotKB:
Q08012
UniParc:
UPI00000017E7
EMBL:
L12446,
AY135061,
AY135056,
AY135067,
AY135053,
AE013599,
L13173,
AY135059,
AY135058,
AY135068,
AY135063,
AY135069,
AY061142,
AY135066,
AY135071,
AY135055,
AY135073,
AY135064,
AY135062,
AY135070,
AY135057,
AY135072,
AY135074,
AY135054,
AY135060,
AY135065
EnsemblGenome:
FBgn0004638
KO:
dme:Dmel_CG6033
|
| Nucleutide sequences |
EMBL-CDS:
AAN17568.1,
AAN17573.1,
AAN17579.1,
AAN17572.1,
AAN17577.1,
AAN17585.1,
AAA28898.1,
AAN17582.1,
AAN17575.1,
AAN17566.1,
AAM68585.1,
AAM68584.1,
AAN17564.1,
AAN17567.1,
AAN17565.1,
AAF58368.1,
AAN17583.1,
AAM68583.1,
AAN17584.1,
AAN17570.1,
AAN17578.1,
AAN17581.1,
AAM68582.1,
AAL28690.1,
AAN17580.1,
AAN17569.1,
AAN17571.1,
AAN17574.1,
AAN17576.1
Gene_ORFName:
CG6033
EnsemblGenome_TRS:
FBtr0087694,
FBtr0087697,
FBtr0087696,
FBtr0087698,
FBtr0087695
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0086813,
FBpp0086817,
FBpp0086816,
FBpp0086815,
FBpp0086814
RefSeq:
NP_725302.1,
NP_476858.1,
NP_725304.1,
NP_725303.1,
NP_725306.1
|
| Others |
UniRef100:
UniRef100_Q08012
UniRef90:
UniRef90_Q08012
UniRef50:
UniRef50_Q08012
UniGene:
Dm.3707
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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