| Type | Description |
|---|---|
| Definition | Mre11 complex subunit Nbs1 |
| Date | Results | Publications |
|---|---|---|
| 2017-07-15 11:54:00 | a mre11 mutant defective in endonucleolytic activity, the same mutant lacking Ctp1, or the triple mutant also lacking the putative hairpin nuclease Pso2 showed wild-type levels of repair. Thus, MRN (Mre11-Rad50-Nbs1)may act to recruit the hairpin opening activity that allows subsequent repair | 28292918 |
| 2012-01-28 11:49:00 | these data propose that release of the MRN complex and Ku from DNA ends by Mre11 nuclease activity and Ctp1 is a critical step required to expose ssDNA for replication protein A localization and ensuing homologous recombination repair. | 21931565 |
| 2010-08-23 11:43:00 | Mre11-Rad50-Nbs1 participates in checkpoint-dependent replication slowing through negative regulation of recombination. | 20065069 |
| 2010-01-21 00:00:00 | Study finds that in the presence of the MRN (Rad32-Rad50-Nbs1) complex efficient recombination requires Ctp1, the ortholog of the nuclease Sae2, but not the nuclease activity of MRN. | 19470480 |
| 2010-01-21 00:00:00 | Tethering of Ctp1 to a flexible Nbs1 arm suggests a mechanism for restricting DNA end processing and homologous recombination activities of Sae2/Ctp1/CtIP to the immediate vicinity of double-strand breaks. | 19804755 |
| Type | IDs |
|---|---|
| Synonymous | slr10 |
| Gene |
UniProtKB-ID:
NBS1_SCHPO
UniprotKB:
O43070
UniParc:
UPI0000183DF7
EMBL:
AB099299,
CU329671,
AY269280
EnsemblGenome:
SPBC6B1.09c
KO:
spo:SPBC6B1.09c
|
| Nucleutide sequences |
EMBL-CDS:
AAP32157.1,
CAD88196.1,
BAC80248.1
Gene_ORFName:
SPBC6B1.09c
EnsemblGenome_TRS:
SPBC6B1.09c.1
|
| Protein sequencees |
EnsemblGenome_PRO:
SPBC6B1.09c.1:pep
RefSeq:
NP_001018823.1
|
| Others |
UniRef100:
UniRef100_O43070
UniRef90:
UniRef90_O43070
UniRef50:
UniRef50_O43070
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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