| Type | Description |
|---|---|
| Definition | collagen and calcium binding EGF domains 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-04-13 11:42:00 | During mouse embryonic stem cell (ESC) differentiation Ccbe1 is upregulated upon emergence of Isl1- and Nkx2.5- positive cardiac progenitors. Ccbe1 is enriched in Isl1-positive cardiac progenitors isolated from ESCs differentiating in vitro or embryonic hearts developing in vivo. Disruption of Ccbe1 activity by shRNA knockdown or blockade with a neutralizing antibody results in impaired differentiation of ESCs. | 30281646 |
| 2019-01-12 12:00:00 | Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. | 28687807 |
| 2018-12-22 11:54:00 | CCBE1 is essential for coronary vessel formation, independent of their embryonic origin, and is also necessary for peritruncal vessel growth and proper CA stem patterning. | 30204931 |
| 2015-07-25 11:06:00 | Collagen domains of CCBE1 are crucial for the activation of VEGFC in vitro and in vivo. The EGF domains of CCBE1 are dispensable for regulation of VEGFC processing in vitro, however, they are necessary for full lymphangiogenic activity of CCBE1 in vivo. | 25814692 |
| 2014-10-04 12:47:00 | CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. | 24552833 |
| Type | IDs |
|---|---|
| Synonymous | 4933426F18Rik, 9430093N24Rik, mKIAA1983 |
| Gene |
UniProtKB-ID:
CCBE1_MOUSE
UniprotKB:
Q3MI99
UniParc:
UPI00000EBA9C
EMBL:
AK028377,
BC103803,
AK220435,
BC152322,
AK039742,
AK035153
Ensembl:
ENSMUSG00000046318
KO:
mmu:320924
|
| Nucleutide sequences |
EMBL-CDS:
BAC25916.1,
AAI03804.1,
BAD90476.1,
BAC28962.1,
AAI52323.1,
BAC30435.1
Ensembl_TRS:
ENSMUST00000061103,
ENSMUST00000130300
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000052011,
ENSMUSP00000117636
RefSeq:
XP_036017069.1,
NP_848908.1,
XP_036017070.1,
XP_006526084.1
|
| Others |
UniRef100:
UniRef100_Q3MI99
UniRef90:
UniRef90_Q6UXH8
UniRef50:
UniRef50_Q6UXH8
UniGene:
Mm.442049
CCDS:
CCDS29314.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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