Repression by PRDM13 is critical for generating precision in neuronal identity.
Elife. 2017 Aug 29;6. doi:10.7554/eLife.25787
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摘要
are excluded dorsally. PRDM13 does this via recruitment to chromatin by multiple neural bHLH factors to restrict gene expression in specific neuronal lineages. Together these findings highlight the function of PRDM13 in repressing the activity of bHLH transcriptional activators that together are required to achieve precise neuronal specification during mouse development.
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基因功能
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原始数据
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文献解读
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