| Type | Description |
|---|---|
| Definition | ligase IV, DNA, ATP-dependent |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 10:17:00 | Hypomorphic Lig4 mutation Promotes nonprogressive microcephaly. | 31541646 |
| 2016-05-21 13:03:00 | The data firmly demonstrate Lig4(R278H) activity renders nonhomologous end-joining (NHEJ) DNA repair to be more error-prone, and predict increased error-prone NHEJ and A-EJ suppression as the cause of defective B lymphopoiesis in Lig4 patients. | 26608917 |
| 2016-02-13 11:35:00 | To promote homology-directed r at the expense of nonhomologous end joining , we targeted DNA ligase IV, a key enzyme in the NHEJ pathway, using the inhibitor Scr7. This approach should be applicable to other customizable endonucleases | 25798939 |
| 2012-05-12 10:22:00 | Lig4 and XRCC1 double-deficient cells switch as efficiently as Lig4-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination | 22392994 |
| 2011-09-10 11:00:00 | These studies provide insight into the interplay between DNA damage responses in the developing brain and the DNA ligase IV plat the role in repairing endogenously arising DNA double-strand breaks. | 21734301 |
| Type | IDs |
|---|---|
| Synonymous | 5830471N16Rik, tiny |
| Gene |
UniProtKB-ID:
DNLI4_MOUSE
UniprotKB:
Q8BTF7
UniParc:
UPI000024EDF2
EMBL:
CH466566,
AK030029,
AK148081,
AC138397
Ensembl:
ENSMUSG00000049717
KO:
mmu:319583
|
| Nucleutide sequences |
EMBL-CDS:
BAC26747.1,
EDL22040.1,
BAE28333.1,
EDL22038.1
Ensembl_TRS:
ENSMUST00000095476,
ENSMUST00000170033
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000130807,
ENSMUSP00000093130
RefSeq:
NP_795927.2,
NP_001363971.1
|
| Others |
UniRef100:
UniRef100_Q8BTF7
UniRef90:
UniRef90_Q8BTF7
UniRef50:
UniRef50_Q8BTF7
UniGene:
Mm.80584
CCDS:
CCDS22092.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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