| Type | Description |
|---|---|
| Definition | glypican 4 |
| Date | Results | Publications |
|---|---|---|
| 2017-05-27 10:55:00 | According to behavioral studies, downregulation of Gpc4 by Gpc4 siRNA decreased spontaneous seizure frequency, while upregulation of Gpc4 by recombinant Gpc4 overexpression led to a converse result. These findings support the hypothesis that increased expression of Gpc4 in the brain is associated with epileptic seizures. | 27425250 |
| 2015-05-09 12:38:00 | GPC-4 showed strong (nanomolar) affinity and heparan sulfate-dependent interaction with the Ig domains of PTPsigma in rat brain synapses. | 25624497 |
| 2012-08-18 10:22:00 | data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses | 22722203 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
Q642B0_RAT
UniprotKB:
Q642B0
UniParc:
UPI0000250033
EMBL:
BC081962,
AABR07041778
Ensembl:
ENSRNOG00000002413
KO:
rno:317322
|
| Nucleutide sequences |
EMBL-CDS:
AAH81962.1
Ensembl_TRS:
ENSRNOT00000003282
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000003282
RefSeq:
XP_006257642.1,
NP_001014130.1
|
| Others |
UniRef100:
UniRef100_Q642B0
UniRef90:
UniRef90_O75487
UniRef50:
UniRef50_O75487
UniGene:
Rn.19945
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29276006 |
WNT Signaling Perturbations Underlie the Genetic Heterogeneity of Robinow Syndrome. Am J Hum Genet Janson J White , Juliana F Mazzeu , Zeynep Coban-Akdemir , Yavuz Bayram , Vahid Bahrambeigi , Alexander Hoischen , Bregje W M van Bon , Alper Gezdirici , Elif Yilmaz Gulec , Francis Ramond , Renaud Touraine , Julien Thevenon , Marwan Shinawi , Erin Beaver , Jennifer Heeley , Julie Hoover-Fong , Ceren D Durmaz , Halil Gurhan Karabulut , Ebru Marzioglu-Ozdemir , Atilla Cayir , Mehmet B Duz , Mehmet Seven , Susan Price , Barbara Merfort Ferreira , Angela M Vianna-Morgante , Sian Ellard , Andrew Parrish , Karen Stals , Josue Flores-Daboub , Shalini N Jhangiani , Richard A Gibbs , Baylor-Hopkins Center for Mendelian Genomics , Han G Brunner , V Reid Sutton , James R Lupski , Claudia M B Carvalho |
2018-01-04 | - |
| 27425250 |
Biochem. Biophys. Res. Commun. Yan Xiong , Yanke Zhang , Fangshuo Zheng , Yong Yang , Xin Xu , Wei Wang , Binglin Zhu , Xuefeng Wang |
2016-09-09 | - |
| 25931508 |
Mol Cell Proteomics Joseph Mertz , Haiyan Tan , Vishwajeeth Pagala , Bing Bai , Ping-Chung Chen , Yuxin Li , Ji-Hoon Cho , Timothy Shaw , Xusheng Wang , Junmin Peng |
2015-07-01 | - |
| 25624497 |
Proc. Natl. Acad. Sci. U.S.A. Ji Seung Ko , Gopal Pramanik , Ji Won Um , Ji Seon Shim , Dongmin Lee , Kee Hun Kim , Gug-Young Chung , Giuseppe Condomitti , Ho Min Kim , Hyun Kim , Joris de Wit , Kang-Sik Park , Katsuhiko Tabuchi , Jaewon Ko |
2015-02-10 | - |
| 24006456 |
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. Mélanie Abonnenc , Adam A Nabeebaccus , Ursula Mayr , Javier Barallobre-Barreiro , Xuebin Dong , Friederike Cuello , Sumon Sur , Ignat Drozdov , Sarah R Langley , Ruifang Lu , Konstantina Stathopoulou , Athanasios Didangelos , Xiaoke Yin , Wolfram-Hubertus Zimmermann , Ajay M Shah , Anna Zampetaki , Manuel Mayr |
2013-10-25 | - |
| 23911103 |
Neuron Joris de Wit , Matthew L O'Sullivan , Jeffrey N Savas , Giuseppe Condomitti , Max C Caccese , Kristel M Vennekens , John R Yates , Anirvan Ghosh |
2013-08-21 | - |
| 23376485 |
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. J Proteomics Marco Prunotto , Annarita Farina , Lydie Lane , Agnès Pernin , Jürg Schifferli , Denis F Hochstrasser , Pierre Lescuyer , Solange Moll |
2013-04-26 |
CDH2,
GNPDA1,
C1orf68,
PDCD6IP,
PDCD6,
TOM1L1,
CDH6,
IL18BP,
DPP3,
SNUPN,
ARPC5,
CDH11,
ARPC4,
ARPC3,
ARPC1B,
ACTR3,
ACTR2,
TSPAN1,
ARPC2,
ACTR1B,
ACTR1A,
CDH13,
PDIA6,
TRAP1,
PDZK1IP1,
ATP6AP2,
DHRS2,
NUTF2,
FLOT1,
PSMD14,
RIDA,
GLYAT,
ZMPSTE24,
STUB1,
RTN3,
LANCL1,
CRISP3,
SIRPB1,
AKR1A1,
TFG,
TUBA1B,
BPNT1,
TUBB4B,
BTN2A2,
NDRG1,
RACK1,
ST3GAL6,
CPQ,
WFDC2,
BASP1,
IFITM3,
CDSN,
LYPLA1,
FAM3C,
ACAA2,
VAV3,
TOMM40,
BAIAP2,
ATP5H,
CEACAM5,
CAP1,
VAT1,
FBLN5,
CIB1,
GLRX3,
PROCR,
ARL6IP5,
ARPC1A,
OLFM4,
CEL,
CCT7,
CCT4,
CCT2,
NPC2,
DNPH1,
PAICS,
MYL12A,
ATP5L,
YKT6,
PMVK,
GNA13,
B3GNT2,
CCT8,
CETP,
CFL1,
PTGES3,
RBBP9,
MASP2,
CTSC,
GIPC1,
AHCYL1,
IQGAP2,
VAMP5,
CFTR,
ALDH1L1,
FTCD,
RUVBL2,
PGRMC1,
FGL2
|
| 22722203 |
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. Nature Nicola J Allen , Mariko L Bennett , Lynette C Foo , Gordon X Wang , Chandrani Chakraborty , Stephen J Smith , Ben A Barres |
2012-06-21 |
Gpc4,
Gria1,
Gpc6,
Gpc4
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21630459 |
Proteomic characterization of the human sperm nucleus. Proteomics Sara de Mateo , Judit Castillo , Josep Maria Estanyol , José Luis Ballescà , Rafael Oliva |
2011-07-01 |
DNAJB6,
GPC6,
PSME3,
PSMD14,
KATNB1,
TUBB3,
TUBB4A,
TUBB4B,
PRDX4,
AKAP3,
CENPA,
C6orf10,
PTGES3,
ACTL7A,
TOMM34,
RCC1,
ZPBP,
NUDT5,
TUBA3E,
PARK7,
IZUMO4,
PHB2,
TUBA3D,
PTPMT1,
HIST4H4,
C16orf78,
ZPBP2,
HIST2H3C,
TMCO2,
HMGB4,
HIST3H2BB,
LYZL4,
NUDT16,
GNPDA2,
EVC2,
PACRG,
PRSS37,
DYNLL2,
RPL10L,
BANF2,
CS,
PSMA8,
SLC2A14,
CSNK2A1,
CSNK2A2,
CSNK2B,
TEKT5,
SLC25A10,
TMEM190,
FAM71A,
TEKT4,
CTSG,
FAM81B,
CYC1,
FAM71B,
CYLC1,
CYLC2,
EEF1A1P5,
DNAJB8,
DECR1,
CRISP1,
DGUOK,
DLST,
DSP,
EEF1A1,
EEF1D,
EEF1G,
EEF2,
FAM209A,
ENO1,
TUBB,
CT83,
ALAD,
ALB,
ARMC12,
HIST1H2AA,
GPC4,
ALDOA,
FLG,
PSME4,
DNAJC9,
SYNE1,
SUZ12,
RPL13A,
DNPEP,
GTPBP4,
TSSK2,
MTCH2,
FTH1,
HIST1H2BA,
MPC2,
DPCD,
FAM205A,
NIPSNAP3A,
GAPDH,
TKFC,
TES,
RIBC2,
CABYR
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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