| Type | Description |
|---|---|
| Definition | dermatan sulfate epimerase |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:57:00 | Dermatan sulfate epimerase 1 expression and mislocalization may interfere with dermatan sulfate synthesis and breast cancer cell growth. | 31972438 |
| 2019-03-09 10:10:00 | DS-epi1, DS-epi2, and D4ST1 form homomers and are all part of a hetero-oligomeric complex where D4ST1 directly interacts with DS-epi1, but not with DS-epi2. The cooperation of DS-epi1 with D4ST1 may therefore explain the processive mode of the formation of iduronic acid blocks. | 29976758 |
| 2018-12-22 11:17:00 | Study showed that DSE is frequently upregulated in human glioma tissue and cell lines and associated with a worse tumor grade and poor overall survival. Its knockdown suppresses malignant phenotypes, whereas DSE overexpression enhances glioma cell malignancy, both in vitro and in vivo. Mechanically, DSE modulates HB-EGF-induced EGFR/ErbB2 activity and downstream signaling. | 29864158 |
| 2014-03-22 11:10:00 | study identified a homozygous DSE missense mutation (c.803C>T, p.S268L) in a male child with musculocontractural type of Ehlers-Danlos syndrome; data indicate mutation affects the epimerase activity, resulting in reduced dermatan sulfate (DS) biosynthesis and an increased synthesis or an accumulation or reduced conversion of chondroitin sulfate | 23704329 |
| 2012-06-02 11:34:00 | Dermatan sulfate epimerase 1 was highly upregulated in esophagus squamous cell carcinoma | 22350411 |
| Type | IDs |
|---|---|
| Synonymous | DS-epi1, DSEP, DSEPI, EDSMC2, SART-2, SART2 |
| Gene |
UniProtKB-ID:
DSE_HUMAN,
B7Z1T3_HUMAN,
A0A2U3TZJ0_HUMAN,
A0A2R8YE23_HUMAN,
B7Z765_HUMAN
UniprotKB:
Q9UL01,
B7Z1T3,
A0A2U3TZJ0,
A0A2R8YE23,
B7Z765
UniParc:
UPI0001914AEC,
UPI0000073CB8,
UPI000191520A,
UPI0007AA7D59,
UPI0007AA7D88
EMBL:
AL050331,
Z84488,
AF098066,
BC039245,
AL590542,
AK293872,
AK301513
Ensembl:
ENSG00000111817
KO:
hsa:29940
|
| Nucleutide sequences |
EMBL-CDS:
AAF00087.1,
AAH39245.1,
BAH11619.1,
BAH13501.1
Ensembl_TRS:
ENST00000452085,
ENST00000331677,
ENST00000644252,
ENST00000359564,
ENST00000647244,
ENST00000646710
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000404049,
ENSP00000332151,
ENSP00000494147,
ENSP00000352567,
ENSP00000495184,
ENSP00000495970
RefSeq:
NP_001309869.1,
NP_001309873.1,
NP_001309868.1,
NP_001361451.1,
NP_001361449.1,
NP_001309867.1,
NP_001361450.1,
XP_016866286.1,
XP_016866285.1,
NP_001309872.1,
NP_001074445.1,
NP_001309866.1,
XP_016866284.1,
NP_037484.1,
NP_001309870.1
|
| Others |
UniRef100:
UniRef100_Q9UL01,
UniRef100_B7Z1T3,
UniRef100_A0A2U3TZJ0,
UniRef100_A0A2R8YE23
UniRef90:
UniRef90_B7Z1T3,
UniRef90_A0A2R8YE23,
UniRef90_A0A2U3TZJ0,
UniRef90_Q9UL01
UniRef50:
UniRef50_A0A5G2RGF2,
UniRef50_B7Z1T3,
UniRef50_A0A2R8Y6J1,
UniRef50_Q9UL01
UniGene:
Hs.458358
CCDS:
CCDS5107.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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