| Type | Description |
|---|---|
| Definition | guanylate cyclase activator 2A |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:42:00 | APC-beta-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. | 32037952 |
| 2018-12-29 10:19:00 | Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes. | 29289697 |
| 2018-02-24 10:14:00 | Both guanylin and uroguanylin trigger lipolysis in human visceral adipocytes. Given the lipolytic action of the guanylin system on visceral adipocytes, the herein reported decrease of circulating prouroguanylin concentrations in obese patients may have a role in excessive fat accumulation in obesity. | 27108812 |
| 2018-01-27 11:56:00 | Results demonstrate that GC-C and its ligands, guanylin and uroguanylin are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C signaling pathway may be implicated in the progression of UC. | 27125248 |
| 2017-05-20 12:02:00 | The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines. | 27044258 |
| Type | IDs |
|---|---|
| Synonymous | GCAP-I, GUCA2, STARA |
| Gene |
UniProtKB-ID:
GUC2A_HUMAN
UniprotKB:
Q02747
UniParc:
UPI000013CC23
EMBL:
AC114492,
X74322,
M97496,
M95174
Ensembl:
ENSG00000197273
KO:
hsa:2980
|
| Nucleutide sequences |
EMBL-CDS:
AAA58625.1,
AAA35915.1,
CAC22258.1
Ensembl_TRS:
ENST00000357001
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000349493
RefSeq:
NP_291031.2
|
| Others |
UniRef100:
UniRef100_Q02747
UniRef90:
UniRef90_Q02747
UniRef50:
UniRef50_Q02747
UniGene:
Hs.778
CCDS:
CCDS465.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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