| Type | Description |
|---|---|
| Definition | RAP1A, member of RAS oncogene family |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:32:00 | Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics. | 32452765 |
| 2020-06-27 12:14:00 | that RAP1A was a direct target gene of miR-202 in the PC12 cell. RAP1A expression was upregulated in the spinal dorsal horn of bilateral sciatic nerve chronic constriction injury (bCCI)rat. | 30520098 |
| 2019-12-28 12:19:00 | These findings suggest that TGFbeta1 regulates Rap1, resulting in the suppression of RhoA, activation of and formation of Factin during the migration of hepatic stellate cells. | 31173168 |
| 2017-02-18 10:24:00 | Data suggest activation of EPAC1/2 (exchange proteins activated by cAMP) and Rap1 (RAS-related GTP-binding protein 1) in hepatic stellate cells down-regulates proliferation and synthesis of a-smooth muscle actin/collagen I/collagen II in an in vitro model of alcoholic cirrhosis (AC); in AC, expression of EPAC1 is down-regulated but expression of EPAC2 is up-regulated; EPAC1 activation increases GTP-bound (activated) Rap1. | 26854595 |
| 2015-05-09 12:35:00 | Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. | 25533468 |
| Type | IDs |
|---|---|
| Synonymous | RAP-1A, rap 1A |
| Gene |
UniProtKB-ID:
RAP1A_RAT
UniprotKB:
P62836
UniParc:
UPI0000001250
EMBL:
BC083813
Ensembl:
ENSRNOG00000032463
KO:
rno:295347
|
| Nucleutide sequences |
EMBL-CDS:
AAH83813.1
Ensembl_TRS:
ENSRNOT00000047836
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000040409
RefSeq:
NP_001005765.1
|
| Others |
UniRef100:
UniRef100_P62834
UniRef90:
UniRef90_P62834
UniRef50:
UniRef50_P62834
UniGene:
Rn.106321
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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