| Type | Description |
|---|---|
| Definition | presenilin 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-26 13:11:00 | Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42 and high Abeta43. | 32265300 |
| 2019-09-14 10:37:00 | results revealed a common, vesicle-type indiscriminate trafficking defect in PS1DeltaE9 astrocytes | 29392878 |
| 2018-05-05 11:22:00 | Downregulating the expression of miR-375, miR-30a, and miR-34a restored PSEN1, PSEN2, and NICD1 production and prevented glucotoxicity-induced impairment of the beta cells.Our findings demonstrated that miRNA-mediated suppression of NICD1 links the presenilin/Notch1 pathway to glucotoxicity in mature pancreatic beta cells | 27804997 |
| 2017-11-26 01:48:00 | Cultured hippocampal neurons expressing mutant PS1 had attenuated CCE that was associated with destabilized dendritic spines, which were rescued by either gamma-secretase inhibition or overexpression of STIM1. | 27601731 |
| 2017-05-27 10:26:00 | PS1 expression is triggered by glutamate through p38alpha, contributing to the excitotoxic stimulus of EW | 27278235 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PSN1_RAT
UniprotKB:
P97887
UniParc:
UPI00001327D9
EMBL:
D82363,
D82578,
BC070887
Ensembl:
ENSRNOG00000009110
KO:
rno:29192
|
| Nucleutide sequences |
EMBL-CDS:
AAH70887.1,
BAA11575.1,
BAA11564.1
Ensembl_TRS:
ENSRNOT00000012495
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000012495
RefSeq:
XP_006240383.1,
XP_006240384.1,
NP_062036.2
|
| Others |
UniRef100:
UniRef100_P97887
UniRef90:
UniRef90_P49769
UniRef50:
UniRef50_P49768
UniGene:
Rn.44440
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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