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28185 Tomm70a

28185

Tomm70a

translocase of outer mitochondrial membrane 70A

protein-coding

Mus musculus

基因描述

Type Description
Definition translocase of outer mitochondrial membrane 70A

研究结论

Date Results Publications
2019-07-06 12:00:00 TOM70, but not TOM20, clusters in distinct OMM foci, frequently overlapping with sites in which the endoplasmic reticulum (ER) contacts mitochondria. Functionally, TOM70 depletion specifically impairs inositol trisphosphates (IP3)-linked ER to mitochondria Ca(2+) transfer. This phenomenon is dependent on the capacity of TOM70 to interact with IP3-receptors and favor their functional recruitment close to mitochondria. 29395920
2018-05-19 10:28:00 Genetic manipulation revealed that loss of Tom70 decreased mitochondrial MICU1 localization and aggravated myocardial ischemia/reperfusion injury; whereas, overexpression of Tom70 protected myocardial ischemia/reperfusion injury, which was eliminated by MICU1 ablation. 28703803
2017-04-22 12:44:00 Our findings showed that Tom70 is essential for melatonin-induced protection against post-myocardial infarction injury 27706848
2013-12-07 11:54:00 PINK1 is imported into mitochondria by a unique pathway that is independent of the TOM core complex but crucially depends on the import receptor Tom70 23472196
2010-01-21 00:00:00 S100A2 and S100A6 interact with another TPR protein Tom70 and regulate the Tom70-ligand interaction in vitro 18669640

名称对应

Type IDs
Synonymous 2610044B22Rik, D16Ium22, D16Ium22e, D16Wsu109e, Tom70, Tomm70, mKIAA0719
Gene
UniProtKB-ID: TOM70_MOUSE
UniprotKB: Q9CZW5
UniParc: UPI00000EB1D3
EMBL: BC139420, AK012084, AK083586, BC057096, AK150429, BC139421, AK145458
Ensembl: ENSMUSG00000022752
KO: mmu:28185
Nucleutide sequences
EMBL-CDS: BAE26448.1, AAI39421.1, AAI39422.1, BAC38960.1, BAE29552.1, AAH57096.1, BAB28018.1
Ensembl_TRS: ENSMUST00000166897
Protein sequencees
Ensembl_PRO: ENSMUSP00000129186
RefSeq: NP_613065.2
Others
UniRef100: UniRef100_Q9CZW5
UniRef90: UniRef90_O94826
UniRef50: UniRef50_O94826
UniGene: Mm.213292
CCDS: CCDS28227.1

全选

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