| Type | Description |
|---|---|
| Definition | tropomyosin 1 |
| Date | Results | Publications |
|---|---|---|
| 2015-09-26 13:14:00 | The first step of hypertrophic cardiomyopathy pathogenesis with E99K is increased calcium sensitivity and decreased calcium cooperativity, which result in larger tension during partial activation to cause a diastolic problem. | 25451174 |
| 2013-07-20 12:20:00 | over-inhibition of the actomyosin interaction by E40K and E54K Tm mutants leads to a decreased force-generating ability at systole, which is the main mechanism underlying the early pathogenesis of DCM. | 23077624 |
| 2010-11-13 10:31:00 | The tendency of smooth muscle tropomyosin to form semi-rigid polymers with continuous and undampened rigidity may compensate for the lack of troponin-based structural support in smooth muscles. | 20682264 |
| 2010-01-21 00:00:00 | Deletion of regions 2-3 in tropomyosin alpha resulted in an 60 % decrease in both isometric tension and stiffness of tropomyosin-reconstituted myocardium. | 14500764 |
| 2010-01-21 00:00:00 | Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules | 16980359 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TPM1_BOVIN
UniprotKB:
Q5KR49
UniParc:
UPI00004B24AE
EMBL:
AB198070,
BC102909
Ensembl:
ENSBTAG00000005373
KO:
bta:281544
|
| Nucleutide sequences |
EMBL-CDS:
BAD86590.1,
AAI02910.1
Ensembl_TRS:
ENSBTAT00000044796
|
| Protein sequencees |
Ensembl_PRO:
ENSBTAP00000042255
RefSeq:
XP_024853025.1,
XP_024853026.1,
XP_024853014.1,
XP_024853028.1,
XP_024853022.1,
NP_001013608.1,
XP_024853018.1,
XP_024853015.1,
XP_024853021.1,
XP_024853016.1,
XP_024853024.1,
XP_024853019.1,
XP_024853012.1,
XP_024853020.1,
XP_024853023.1,
XP_024853029.1,
XP_024853027.1,
XP_024853017.1,
XP_024853013.1
|
| Others |
UniRef100:
UniRef100_Q5KR49
UniRef90:
UniRef90_Q5KR49
UniRef50:
UniRef50_P09493
UniGene:
Bt.109484
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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