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2799 GNS

2799

GNS

glucosamine (N-acetyl)-6-sulfatase

protein-coding

Homo sapiens

基因描述

Type Description
Definition glucosamine (N-acetyl)-6-sulfatase

研究结论

Date Results Publications
2017-05-20 14:00:00 Mice deficient in GNS showed lysosomal storage pathology and a phenotype that closely resembled human MPSIIID. Moreover, treatment of the GNS-deficient animals with GNS-encoding adeno-associated viral (AAV) vectors of serotype 9 delivered to the cerebrospinal fluid completely corrected pathological storage, improved lysosomal functionality in the CNS and somatic tissues, resolved neuroinflammation 28334745
2010-08-02 12:19:00 12 new patients and 15 novel mutations were identified in Mucopolysaccharidosis type IIID. 20232353
2010-01-21 00:00:00 The Sanfilippo syndrome type D patient was found to be homozygous for a single base pair deletion (c1169delA), which will cause a frameshift and premature termination of N-acetylglucosamine-6-sulphatase. 12624138
2010-01-21 00:00:00 Sanfilippo syndrome type D has 3 novel mutations in the GNS Gene. 17998446
2010-01-21 00:00:00 A large intragenic deletion of 8723 bp encompassing exons 2 and 3 has been identified, the first large intragenic deletion to be reported in any of the four Sanfilippo subtypes. Q272X has also been found. 16990043

名称对应

Type IDs
Synonymous G6S
Gene
UniProtKB-ID: GNS_HUMAN, Q7Z3X3_HUMAN, A0A024RBC5_HUMAN
UniprotKB: P15586, Q7Z3X3, A0A024RBC5
UniParc: UPI00001A995B, UPI0000000CC8, UPI00001FC6C4
EMBL: AK302443, BC012482, BX537363, KU178097, CH471054, AC025262, AK223484, Z12173
Ensembl: ENSG00000135677
KO: hsa:2799
Nucleutide sequences
EMBL-CDS: AAH12482.1, CAA78164.1, BAG63740.1, BAD97204.1, CAD97608.1, EAW97140.1, EAW97138.1, ALQ33555.1
Gene_ORFName: hCG_1640559
Ensembl_TRS: ENST00000542058, ENST00000258145
Protein sequencees
Ensembl_PRO: ENSP00000444819, ENSP00000258145
RefSeq: NP_002067.1
Others
UniRef100: UniRef100_Q7Z3X3, UniRef100_P15586
UniRef90: UniRef90_P15586
UniRef50: UniRef50_P15586
UniGene: Hs.334534
CCDS: CCDS8970.1

全选

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