| Type | Description |
|---|---|
| Definition | cytokine-dependent hematopoietic cell linker |
| Date | Results | Publications |
|---|---|---|
| 2015-09-12 10:07:00 | Clnk is required for TNF-alpha -induced cell death in L929 cells. | 26009488 |
| 2010-01-21 00:00:00 | Clnk is dispensable for normal differentiation and function of T cells, mast cells, and NK cells. Hence, unlike its relatives, Clnk is not essential for normal immune functions | 15199160 |
| 2010-01-21 00:00:00 | is involved in cytokine-mediated up-regulation of MIST gene expression, in collaboration with other lineage-specific transcription factors that promote basal MIST expression in mast cells. | 15358227 |
| 2010-01-21 00:00:00 | interaction of MIST with Fgr, mediated by the C-terminal proline-rich region of MIST and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor-induced IFN-gamma production | 16439675 |
| Type | IDs |
|---|---|
| Synonymous | MIST |
| Gene |
UniProtKB-ID:
CLNK_MOUSE
UniprotKB:
Q9QZE2
UniParc:
UPI0000029F94,
UPI00016277CF
EMBL:
AF187819,
AK082826,
BC125637,
AB021220,
BC125639
Ensembl:
ENSMUSG00000039315
KO:
mmu:27278
|
| Nucleutide sequences |
EMBL-CDS:
BAC38640.2,
AAF14299.1,
BAA96240.1,
AAI25638.1,
AAI25640.1
Ensembl_TRS:
ENSMUST00000169819
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000128473
RefSeq:
NP_038776.3,
XP_006504040.1,
XP_011239037.1,
XP_011239036.1,
XP_006504037.1
|
| Others |
UniRef100:
UniRef100_Q9QZE2
UniRef90:
UniRef90_Q9QZE2
UniRef50:
UniRef50_Q9QZE2
UniGene:
Mm.440845
CCDS:
CCDS51486.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32325033 |
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst Reza Pourhaghighi , Peter E A Ash , Sadhna Phanse , Florian Goebels , Lucas Z M Hu , Siwei Chen , Yingying Zhang , Shayne D Wierbowski , Samantha Boudeau , Mohamed T Moutaoufik , Ramy H Malty , Edyta Malolepsza , Kalliopi Tsafou , Aparna Nathan , Graham Cromar , Hongbo Guo , Ali Al Abdullatif , Daniel J Apicco , Lindsay A Becker , Aaron D Gitler , Stefan M Pulst , Ahmed Youssef , Ryan Hekman , Pierre C Havugimana , Carl A White , Benjamin C Blum , Antonia Ratti , Camron D Bryant , John Parkinson , Kasper Lage , Mohan Babu , Haiyuan Yu , Gary D Bader , Benjamin Wolozin , Andrew Emili |
2020-04-22 | - |
| 26009488 |
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929. Biochem. Biophys. Res. Commun. Meng Xu , Chengfeng Cai , Xuli Sun , Wanze Chen , Qinxi Li , Huamin Zhou |
2015-07-31 |
Tnf,
Clnk
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 18203684 |
Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-gamma production. Int. Immunol. Shinya Hidano , Hiroki Sasanuma , Keiko Ohshima , Ken-ichiro Seino , Lalit Kumar , Katsuhiko Hayashi , Masaki Hikida , Tomohiro Kurosaki , Masaru Taniguchi , Raif S Geha , Daisuke Kitamura , Ryo Goitsuka |
2008-03-01 |
Lcp2,
Plcg2,
Clnk
|
| 16439675 |
Blood Hiroki Sasanuma , Akiko Tatsuno , Shinya Hidano , Keiko Ohshima , Yumi Matsuzaki , Katsuhiko Hayashi , Clifford A Lowell , Daisuke Kitamura , Ryo Goitsuka |
2006-05-01 | - |
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 15358227 |
Transcriptional regulation of SLP-76 family hematopoietic cell adaptor MIST/Clnk by STAT5. Biochem. Biophys. Res. Commun. Hiroki Sasanuma , Akiko Tatsuno , Kaori Tsuji , Shinya Hidano , Sumiyo Morita , Toshio Kitamura , Masato Kubo , Daisuke Kitamura , Ryo Goitsuka |
2004-08-13 |
Stat5a,
Clnk,
STAT5A
|
| 15199160 |
Mol. Cell. Biol. Oliver Utting , Bradley J Sedgmen , Tania H Watts , Xiaoshu Shi , Robert Rottapel , Angelo Iulianella , David Lohnes , André Veillette |
2004-07-01 |
Clnk
|
| 12681493 |
Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett Yasuyuki Fujii , Shunichi Wakahara , Toru Nakao , Toshifumi Hara , Hidenori Ohtake , Toshi Komurasaki , Kunihiro Kitamura , Akiko Tatsuno , Naruyoshi Fujiwara , Nobumichi Hozumi , Chisei Ra , Daisuke Kitamura , Ryo Goitsuka |
2003-04-10 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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目前还没有研究热点人员