Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.
Biochem. Biophys. Res. Commun.2015 Jul 31;463(3):275-9. Epub 2015 May 22
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摘要
Clnk, as a third member of the Blnk/SLP-76 adapter family, is involved in the positive regulation of immunoreceptor signaling. Here we provide findings that Clnk may be is required for TNF induced cell death, it functions downstream of RIP3 and promotes TNF- induced generation and MLKL tetramer formation and subsequent necrosis of L929 cells. Therefore, Clnk, as an adaptor protein, may take part in the other cellular processes.
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原始数据
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文献解读
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