| Type | Description |
|---|---|
| Definition | golgi associated, gamma adaptin ear containing, ARF binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-12 10:37:00 | The adaptor, GGA1, and retromer are essential to mediate rapid trafficking of phosphorylated BACE1 to recycling endosomes. Therefore, post-translational phosphorylation of DISLL enhances the exit of BACE1 from early endosomes, a pathway mediated by GGA1 and retromer, which is important in regulating amyloid beta production. | 29142073 |
| 2018-06-02 10:25:00 | full length alpha2B-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop. | 27901063 |
| 2014-09-27 10:59:00 | These findings show that the AD-like phenotype of NPC model cells can be partly reverted by promoting a non-amyloidogenic processing of APP through the upregulation of GGA1 supporting its preventive role against AD | 24866237 |
| 2014-04-26 11:37:00 | These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane. | 24407285 |
| 2012-12-22 10:44:00 | On basis of these results, propose that GGA1 facilitates LR11 endocytic traffic and that LR11 modulates A-beta levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment | 22621900 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
GGA1_HUMAN
UniprotKB:
Q9UJY5
UniParc:
UPI00000739CD,
UPI00003765B2,
UPI000002AA68,
UPI000003E7D9,
UPI0000001BEE,
UPI000000DA9D
EMBL:
CR456493,
AL035496,
BC000538,
AF218584,
CH471095,
AK290548,
BC010917,
AF233521,
Z83844,
AL110219,
AK075256,
AF190862,
BC029388,
BC044629,
AK122898
Ensembl:
ENSG00000100083
KO:
hsa:26088
|
| Nucleutide sequences |
EMBL-CDS:
AAH00538.2,
AAF35393.1,
AAH44629.1,
CAB53679.1,
BAF83237.1,
EAW60169.1,
BAG53788.1,
AAH29388.1,
BAC11501.1,
AAF42847.1,
CAG30379.1,
AAH10917.1,
AAF05707.1
Ensembl_TRS:
ENST00000381756,
ENST00000343632,
ENST00000406772,
ENST00000325180
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000321288,
ENSP00000341344,
ENSP00000371175,
ENSP00000385287
RefSeq:
XP_005261579.1,
XP_016884252.1,
XP_005261577.1,
XP_005261575.1,
NP_037497.1,
XP_016884254.1,
NP_001166159.1,
XP_024307983.1,
XP_016884253.1,
XP_024307985.1,
NP_001350700.1,
XP_011528425.1,
XP_016884250.1,
XP_024307982.1,
NP_001001560.1,
XP_006724292.1,
NP_001166158.1,
XP_024307984.1
|
| Others |
UniRef100:
UniRef100_Q9UJY5
UniRef90:
UniRef90_Q9UJY5
UniRef50:
UniRef50_Q9UJY5
UniGene:
Hs.499158
CCDS:
CCDS87022.1,
CCDS54526.1,
CCDS13951.1,
CCDS33643.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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