-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.

Sci Rep. 2016 Nov 30;6:37921

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摘要

-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop. These studies have identified an important function and revealed novel mechanisms of the GGA family proteins in the forward trafficking of a cell surface GPCR.

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-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.

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