| Type | Description |
|---|---|
| Definition | F-box protein 7 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:56:00 | The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-kappaB signaling pathway. | 33010352 |
| 2019-11-02 11:16:00 | Results suggest that FBXO7 gene doesn't seem to be a risk factor to develop sporadic Parkinson's disease in Chinese population. | 30232368 |
| 2019-04-20 11:40:00 | The pathological mechanisms concerning FBXO7-relevant protein aggregation, mitochondria impairment, reactive oxygen species generation and mitophagy modulation in PARK15 pathogenesis are highlighted and discussed in the current review. | 30454685 |
| 2019-03-16 12:42:00 | we highlight the recent research on FBXO7, which advances our knowledge of the etiopathological pathways and fills unexpected gaps therein, justifying the dedicated study of rare variants of Parkinson disease--{REVIEW} | 29134665 |
| 2018-01-20 11:33:00 | Fbxo7 deficiency is associated with reduced cellular NAD(+) levels, which results in increased mitochondrial NADH redox index and impaired activity of complex I in the electron transport chain. | 27689878 |
| Type | IDs |
|---|---|
| Synonymous | FBX, FBX07, FBX7, PARK15, PKPS |
| Gene |
UniProtKB-ID:
FBX7_HUMAN
UniprotKB:
Q9Y3I1
UniParc:
UPI000012A587,
UPI00002075D6,
UPI00002075D8
EMBL:
AK301716,
AL050254,
AF129537,
AL021937,
AL035068,
AF233225,
CR456491,
AK297841,
BC008361,
Z71183
Ensembl:
ENSG00000100225
KO:
hsa:25793
|
| Nucleutide sequences |
EMBL-CDS:
BAG60175.1,
CAG30377.1,
AAF67155.1,
AAF04471.1,
BAG63187.1,
AAH08361.1,
CAB43356.1
Ensembl_TRS:
ENST00000266087,
ENST00000452138,
ENST00000397426
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000388547,
ENSP00000380571,
ENSP00000266087
RefSeq:
NP_036311.3,
XP_011528408.1,
NP_001028196.1,
NP_001244919.1,
XP_024307975.1
|
| Others |
UniRef100:
UniRef100_Q9Y3I1
UniRef90:
UniRef90_Q9Y3I1
UniRef50:
UniRef50_Q9Y3I1
UniGene:
Hs.5912
CCDS:
CCDS58806.1,
CCDS13907.1,
CCDS46695.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员